Search
Invitrogen
pro-Renin Monoclonal Antibody (434717)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
MA5-61411
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rat
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
434717
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Renin 1, Leu22-Arg402
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with trehalose
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Pro-renin is the precursor form of renin, an enzyme that plays a crucial role in the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure, fluid and electrolyte balance, and systemic vascular resistance. Pro-renin is synthesized and secreted by the juxtaglomerular cells of the kidney. Once in the bloodstream, it can be activated to renin, which then cleaves angiotensinogen to produce angiotensin I. Angiotensin I is subsequently converted to angiotensin II, a potent vasoconstrictor, by the angiotensin-converting enzyme (ACE). Angiotensin II has multiple effects, including increasing blood pressure, stimulating aldosterone secretion from the adrenal glands, and promoting sodium and water reabsorption by the kidneys. Elevated levels of pro-renin and renin are associated with hypertension, heart failure, and chronic kidney disease. Understanding the regulation and function of pro-renin is essential for developing therapeutic strategies aimed at modulating the RAAS pathway to treat cardiovascular and renal diseases. Pro-renin and its receptor also represent potential targets for novel drug development in the management of these conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support