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NeoBiotechnologies
Lewis A (Blood Group Antigen) Monoclonal Antibody (SPM522)
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Product Details
MSM1XX-311-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
SPM522
Immunogen
Mucins isolated from ovarian cyst fluid
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C, do not freeze
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase 3; 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3; 4-fucosyltransferase; 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase; alpha-(1,3/1,4)-fucosyltransferase; Alpha-3-fucosyltransferase FUT3; Blood group Lewis alpha-4-fucosyltransferase; Fucosyltransferase 3; fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group); Fucosyltransferase III; FucT-III; galactoside 3(4)-L-fucosyltransferase; Lewis FT; Lewis Y; unnamed protein product
Gene Aliases: CD174; FT3B; FucT-III; FUT3; LE; Les
UniProt ID: (Human) P21217
Entrez Gene ID: (Human) 2525
protein binding
fucosyltransferase activity
transferase activity
transferase activity, transferring glycosyl groups
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
alpha-(1->3)-fucosyltransferase activity
protein glycosylation
protein N-linked glycosylation
protein O-linked glycosylation
lipid metabolic process
sphingolipid metabolic process
ceramide metabolic process
oligosaccharide metabolic process
oligosaccharide biosynthetic process
cell-cell recognition
positive regulation of cell-cell adhesion
regulation of cell migration
fucosylation
regulation of cell proliferation
macromolecule glycosylation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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