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Invitrogen
Fibulin 1 Polyclonal Antibody
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Product Details
PA5-51613
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human Fibulin 1. Recombinant protein control fragment (Product #RP-100522).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Amount
10 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NTLGSYLCSC SVGFRLSVDG RSCEDINECS SSPCSQECAN VYGSYQCYCR RGYQLSDVDG VTCEDIDECA LPTGGHICSY RCINIPGSFQ CSCPSSGYRL APNGRNCQDI DECVTGIHNC SINETCFNIQ GGFRCLAFEC PEN
Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.
Target Information
Fibulin-1 is a modular glycoprotein component of the elastic extracellular matrix fibers, basement membranes and blood. Fibulin-1 self associates as well as binds to calcium, fibronectin, laminin, nidogen and fibrinogen. These interactions, individually or in combination, may account for the observed association of Fibulin-1 with basement membranes, connective tissue, elastic fibers and fibrin clots. Fibulin-1 expression is stimulated by estrogen in ovarian cancer cell lines and has been suggested as both an agent of metastasis in ovarian cancer cells and an indicator for predicting cancer risk or aggressiveness in ovarian carcinomas. Other studies point to the inhibition of cancer cell motility with increasing exposure to Fibulin-1. The exact function of Fibulin-1 in the cell is unknown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FIBL-1; Fibulin-1; Fibulin1; unnamed protein product
Gene Aliases: FBLN; FBLN1; FIBL1; PP213
UniProt ID: (Human) P23142
Entrez Gene ID: (Human) 2192
negative regulation of protein phosphorylation
negative regulation of cell adhesion
integrin-mediated signaling pathway
embryo implantation
positive regulation of gene expression
extracellular matrix organization
positive regulation of fibroblast proliferation
negative regulation of ERK1 and ERK2 cascade
negative regulation of transforming growth factor beta production
blood coagulation, fibrin clot formation
negative regulation of substrate adhesion-dependent cell spreading
negative regulation of transformation of host cell by virus
positive regulation of substrate-dependent cell migration, cell attachment to substrate
negative regulation of cell motility
negative regulation of stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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