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Invitrogen
GPLD1 Polyclonal Antibody
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Product Details
PA5-52941
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human GPLD1. Recombinant protein control fragment (Product #RP-102400).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FWSTNIYHLT SFMLENGTSD CNLPENPLFI ACGGQQNHTQ GSKMQKNDFH RNLTTSLTES VDRNINYTER GVFFSVNSWT PDSMSFIYKA LERNIRTMFI GGSQLSQKHV SS
Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 68%.
Target Information
GPLD1 is expressed in numerous tissues and cells and specifically cleaves GPI-anchored proteins. Liver has the highest level of GPI-PLD expression and is the primary organ contributing to GPLD1 in the serum. GPLD1 is abundant in serum in which it associates with polipoproteins AI and AIV. Increased serum GPLD1 is associated with insulin resistance and elevated serum triglycerides. Many surface proteins are attached to eukaryotic cell membranes via glycosylphosphatidylinositol (GPI) anchors that are covalently bound to the C-terminus of the protein and cleavage of the GPI moiety by GPLD1, only enzyme known that cleavage GPI anchor, may represent a means of regulating attachment of these proteins to the cell surface, or alternatively, their release into the extracellular environment.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Glycoprotein phospholipase D; Glycosyl-phosphatidylinositol-specific phospholipase D; glycosylphosphatidylinositol specific phospholipase D1, isoform 2; GPI-PLD; GPI-specific phospholipase D; MGC22590; Phosphatidylinositol-glycan-specific phospholipase D; PI-G PLD
Gene Aliases: GPIPLD; GPIPLDM; GPLD1; PIGPLD; PIGPLD1; PLD
UniProt ID: (Human) P80108
Entrez Gene ID: (Human) 2822
ossification
cell migration involved in sprouting angiogenesis
chondrocyte differentiation
complement receptor mediated signaling pathway
GPI anchor release
negative regulation of cell proliferation
insulin receptor signaling pathway
response to glucose
positive regulation of endothelial cell migration
positive regulation of alkaline phosphatase activity
positive regulation of triglyceride biosynthetic process
negative regulation of triglyceride catabolic process
positive regulation of glucose metabolic process
positive regulation of high-density lipoprotein particle clearance
cellular response to insulin stimulus
cellular response to drug
hematopoietic stem cell migration
positive regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of apoptotic process
positive regulation of cytolysis
phosphatidylcholine metabolic process
positive regulation of membrane protein ectodomain proteolysis
positive regulation of secretion
transepithelial transport
cellular response to calcium ion
cellular response to cholesterol
cellular response to triglyceride
cellular response to pH
hematopoietic stem cell migration to bone marrow
regulation of cellular response to insulin stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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