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Invitrogen
JIP3 Polyclonal Antibody
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Product Details
PA5-59728
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human JIP3. Recombinant protein control fragment (Product #RP-102915).
Conjugate
Form
Liquid
Concentration
0.1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LDSDVNPEDP GADGVLAGIT LVGCATRCNV PRSNCSSRGD TPVLDKGQGE VATIANGKVN PSQSTEEATE ATEVPDPGPS EPETATLRPG PLTEHVFTDP A
Highest antigen sequence identity to the following orthologs: Mouse - 93%, Rat - 92%.
Target Information
c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members, JNK2 and JNK3, have been identified. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-jun-amino-terminal kinase interacting protein 3; C-Jun-amino-terminal kinase-interacting protein 3; homolog of Drosophila Sunday driver 2; JIP-3; JNK MAP kinase scaffold protein 3; JNK-interacting protein 3; JNK/SAPK-associated protein-1; JNK/stress-activated protein kinase-associated protein 1; Mitogen-activated protein kinase 8-interacting protein 3
Gene Aliases: JIP-3; JIP3; JSAP1; KIAA1066; MAPK8IP3; syd; SYD2
UniProt ID: (Human) Q9UPT6
Entrez Gene ID: (Human) 23162
in utero embryonic development
activation of JUN kinase activity
axon guidance
respiratory gaseous exchange
protein localization
post-embryonic development
regulation of gene expression
vesicle-mediated transport
forebrain development
regulation of JNK cascade
lung alveolus development
lung morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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