Invitrogen

RPS3 Polyclonal Antibody

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Datasheet
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Datasheet
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RPS3 Polyclonal Antibody

Product Details

PA5-64109

Applications
Tested Dilution
Publications

Western Blot (WB)

0.04-0.4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human RPS3. Recombinant protein control fragment (Product #RP-103505).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.05 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2646791

Product Specific Information

Immunogen sequence: NYYVDTAVRH VLLRQGVLGI KVKIMLPWDP TGKIGPKKPL PDHVSIVEPK DEILPTTPIS EQKGGKPEPP AMPQPVPT

Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 99%.

Target Information

WD repeat domain 5 (WDR5) is a member of the WD repeat protein family, which is involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR5, also known as BIG-3, is expressed in the developing growth plate, accelerates chondrocyte and osteoblast differentiation in vitro, and regulates osteoblast differentiation during embryonic bone development. WDR5 interacts with the pluripotency factor Oct4/POU5F1 and is required for the efficient formation of induced pluripotent stem (iPS) cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 40S ribosomal protein S3; FLJ26283; FLJ27450; IMR-90 ribosomal protein S3; MGC87870; OTTHUMP00000229804; OTTHUMP00000229805; OTTHUMP00000229874; OTTHUMP00000229877; OTTHUMP00000229878; OTTHUMP00000229879; OTTHUMP00000229880; OTTHUMP00000229882; OTTHUMP00000229883; OTTHUMP00000229886; Small ribosomal subunit protein uS3

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Gene Aliases: OK/SW-cl.26; RPS3; S3

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UniProt ID: (Human) P23396

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Entrez Gene ID: (Human) 6188

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Function(s)
DNA binding damaged DNA binding RNA binding mRNA binding structural constituent of ribosome DNA-(apurinic or apyrimidinic site) lyase activity endodeoxyribonuclease activity protein binding microtubule binding transcription factor binding tubulin binding DNA N-glycosylase activity enzyme binding kinase binding protein kinase binding Hsp70 protein binding SUMO binding oxidized purine DNA binding oxidized pyrimidine DNA binding ubiquitin-like protein conjugating enzyme binding poly(A) RNA binding protein kinase A binding iron-sulfur cluster binding Hsp90 protein binding small ribosomal subunit rRNA binding supercoiled DNA binding ribosomal protein
Process(es)
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay DNA repair transcription, DNA-templated regulation of transcription, DNA-templated rRNA processing translation translational initiation SRP-dependent cotranslational protein targeting to membrane apoptotic process cellular response to DNA damage stimulus response to oxidative stress chromosome segregation mitotic nuclear division positive regulation of gene expression negative regulation of translation viral transcription positive regulation of microtubule polymerization negative regulation of protein ubiquitination positive regulation of endodeoxyribonuclease activity DNA damage response, detection of DNA damage regulation of apoptotic process positive regulation of JUN kinase activity negative regulation of DNA repair positive regulation of DNA repair spindle assembly cell division response to TNF agonist cellular response to hydrogen peroxide positive regulation of NIK/NF-kappaB signaling positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage positive regulation of DNA N-glycosylase activity positive regulation of base-excision repair positive regulation of apoptotic signaling pathway positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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