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Invitrogen
CNOT2 Polyclonal Antibody
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Product Details
PA5-66949
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human CNOT2. Recombinant protein control fragment (Product #RP-105435).
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: DGSENVTGLDL SDFPALADRN RREGSGNPTP LINPLAGRAP YVGMVTKPAN EQSQDFSIHN EDFPALPGSS YKDPT
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
Target Information
CCR4-NOT Transcription Complex 2 (CNOT2) is a component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. CNOT2 is required for the CCR4-NOT complex structural integrity. It can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. CNOT2 is involved in the maintenance of embryonic stem (ES) cell identity. (UniProt)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex, subunit 2; negative regulator of transcription 2
Gene Aliases: CDC36; CNOT2; HSPC131; MSTP046; NOT2; NOT2H
UniProt ID: (Human) Q9NZN8
Entrez Gene ID: (Human) 4848
negative regulation of transcription from RNA polymerase II promoter
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
nuclear-transcribed mRNA poly(A) tail shortening
trophectodermal cell differentiation
transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
positive regulation of cytoplasmic mRNA processing body assembly
negative regulation of translation
gene silencing by RNA
negative regulation of intracellular estrogen receptor signaling pathway
RNA phosphodiester bond hydrolysis, exonucleolytic
regulation of stem cell population maintenance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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