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Invitrogen
SETD2 Polyclonal Antibody
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Product Details
PA5-83615
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human SETD2. Recombinant protein control fragment (Product #RP-96462).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NLGMTSPLPY DSLGYNAPHH PFAGYPPGYP MQAYVDPSNP NAGKVLLPTP SMDPVCSPAP YDHAQPLVGH STEPLSAPPP VPVVPHVAAP VEVSSSQYVA
Highest antigen sequence indentity to the following orthologs: Rat - 92%, Mouse - 94%.
Target Information
Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate. Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation. Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A. Acts as a key regulator of DNA mismatch repair in G1 and early S phase by generating H3K36me3, a mark required to recruit MSH6 subunit of the MutS alpha complex: early recruitment of the MutS alpha complex to chromatin to be replicated allows a quick identification of mismatch DNA to initiate the mismatch repair reaction. H3K36me3 also plays an essential role in the maintenance of a heterochromatic state, by recruiting DNA methyltransferase DNMT3A. H3K36me3 is also enhanced in intron-containing genes, suggesting that SETD2 recruitment is enhanced by splicing and that splicing is coupled to recruitment of elongating RNA polymerase. Required during angiogenesis. Recruited to the promoters of adenovirus 12 E1A gene in case of infection, possibly leading to regulate its expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: contains WW domain; FLJ16420; FLJ22472; FLJ23184; FLJ45883; HIF-1; HIP-1; Histone-lysine N-methyltransferase SETD2; hSET2; huntingtin interacting protein 1; Huntingtin yeast partner B; Huntingtin-interacting protein 1; Huntingtin-interacting protein B; HYPB; contains WW domain; Lysine N-methyltransferase 3A; p231HBP; Protein-lysine N-methyltransferase SETD2; SET domain-containing protein 2; unnamed protein product
Gene Aliases: HBP231; HIF-1; HIF1; HIP-1; HSPC069; HYPB; KIAA1732; KMT3A; LLS; MRD70; p231HBP; RAPAS; SET2; SETD2
UniProt ID: (Human) Q9BYW2
Entrez Gene ID: (Human) 29072
protein binding
methyltransferase activity
protein-lysine N-methyltransferase activity
transferase activity
histone methyltransferase activity
alpha-tubulin binding
metal ion binding
histone methyltransferase activity (H3-K36 specific)
histone H3 methyltransferase activity
histone H3K36 trimethyltransferase activity
autophagosome assembly
immune system process
DNA repair
mismatch repair
chromatin organization
regulation of transcription, DNA-templated
transcription elongation from RNA polymerase II promoter
cellular response to DNA damage stimulus
response to metal ion
regulation of gene expression
proteasomal protein catabolic process
positive regulation of autophagy
regulation of double-strand break repair via homologous recombination
regulation of mRNA export from nucleus
peptidyl-lysine trimethylation
cell differentiation
methylation
regulation of cytokinesis
positive regulation of interferon-alpha production
response to type I interferon
nucleosome organization
endodermal cell differentiation
response to alkaloid
innate immune response
positive regulation of ossification
stem cell differentiation
defense response to virus
protein K48-linked ubiquitination
microtubule cytoskeleton organization involved in mitosis
regulation of protein localization to chromatin
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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