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Invitrogen
Calreticulin 3 Polyclonal Antibody
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FIGURE: 1 / 7
Calreticulin 3 Antibody (PA5-83911) in IHC (P)
Immunohistochemistry analysis of Calreticulin 3 in human colon, liver, prostate and testis. Samples were incubated with Calreticulin 3 polyclonal antibody (Product # PA5-83911). Shows similar protein distribution across tissues to independent Calreticulin 3 antibody (Product # PA5-83653) (B).
Product Details
PA5-83911
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human CALR3. Recombinant protein control fragment (Product #RP-98460).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SIEYDWNLTS LKKETSPAES KDWEQTKDNK AQDWEKHFLD ASTSKQSDWN GDLDGDWPAP MLQKPPYQDG LKPEGIHKGV WLHRKMKNTD YLTQYDLSEF
Highest antigen sequence indentity to the following orthologs: Rat - 71%, Mouse - 68%.
Target Information
Calreticulin 3 (CALR3) is a gene located on chromosome 19p13.11, encoding a member of the calreticulin family of calcium-binding chaperones. Unlike the more ubiquitously expressed calreticulin (CALR), CALR3 is specifically expressed in the testes and plays a crucial role in spermatogenesis. CALR3 is involved in the quality control of proteins within the endoplasmic reticulum (ER) and assists in the folding and assembly of newly synthesized glycoproteins. This protein's function is essential for the maturation of sperm cells and male fertility, as it helps ensure the proper formation and function of sperm-specific proteins. Mutations in CALR3 have been associated with familial hypertrophic cardiomyopathy, reflecting its potential involvement in cardiac muscle function through mechanisms that remain to be fully elucidated. Research continues to explore CALR3's specific roles in reproductive biology and its implications in hereditary conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Calreticulin-2; Calreticulin-3; Calsperin; cancer/testis antigen 93; testis secretory sperm-binding protein Li 226n
Gene Aliases: CALR3; CMH19; CRT2; CT93
UniProt ID: (Human) Q96L12
Entrez Gene ID: (Human) 125972
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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