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Invitrogen
HFE Polyclonal Antibody
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Product Details
PA5-84157
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HFE. Recombinant protein control fragment (Product #RP-103158).
Conjugate
Form
Liquid
Concentration
0.05 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LGLSLFEALG YVDDQLFVFY DHESRRVEPR TPWVSSRISS QMWLQLSQSL KGWDHMFTVD FWTIMENHNH SKESHTLQVI LGCEMQEDNS TEGYWKYGYD GQDHLEFCPD TLDWRAAEPR AWPTKLEWE
Highest antigen sequence indentity to the following orthologs: Mouse - 72%, Rat - 75%.
Target Information
The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin. It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least nine alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Hereditary hemochromatosis protein; hereditary hemochromatosis protein HLA-H; HFE 1; high Fe; HLA H; HLA-H; MGC10379; MGC103790; MGC:150812; MHC class I-like protein HFE; unnamed protein product
Gene Aliases: HFE; HFE1; HH; HLA-H; HLAH; MVCD7; TFQTL2
UniProt ID: (Human) Q30201
Entrez Gene ID: (Human) 3077
antigen processing and presentation of peptide antigen via MHC class I
regulation of T cell mediated immunity
negative regulation of T cell cytokine production
ion transport
iron ion transport
cellular iron ion homeostasis
receptor-mediated endocytosis
cell surface receptor signaling pathway
response to iron ion
positive regulation of gene expression
antigen processing and presentation
BMP signaling pathway
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
transferrin transport
regulation of iron ion transport
hormone biosynthetic process
positive regulation of receptor-mediated endocytosis
positive regulation of SMAD protein import into nucleus
multicellular organismal iron ion homeostasis
protein-containing complex assembly
cellular response to iron ion
positive regulation of peptide hormone secretion
negative regulation of antigen processing and presentation of endogenous peptide antigen via MHC class I
response to iron ion starvation
regulation of protein localization to cell surface
negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of CD8-positive, alpha-beta T cell activation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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