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Invitrogen
RNF128 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-23164
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Horse,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to amino acids portion of amino acids 227-269 of human GRAIL.
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
1.0 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The amino acid sequence used as immunogen is 100% homologous in chimpanzee, monkey and orangutan, 94% homologous in cow, 88% homologous in cat and 83% homologous in opossum, rat and mouse.
Target Information
GRAIL is a type I transmembrane protein that localizes to the endocytic pathway and contains a PA (protease associated) domain and a RING-type zinc finger domain. It is a ubiquitin-protein isopeptide ligase (E3) necessary for the induction of CD4(+) T cell anergy in vivo and induced expression of this protein was observed in anergic CD4 (+) T cells, which suggested a role in the induction of anergic phenotype. It is differentially expressed in naturally occurring and peripherally induced CD25 (+) T regulatory cells and the expression is linked to the conversion of these cells to a regulatory phenotype. Expression of GRAIL in retrovirally transduced T cell hybridomas limits activation-induced IL-2 and IL-4 cytokine production. It also functions in the patterning of the dorsal ectoderm and sensitizes ectoderm to respond to neural-inducing signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: E3, ring finger ubiquitin ligase; gene related to anergy in lymphocytes protein; goliath-related E3 ubiquitin-protein ligase 1; GREUL1; ring finger protein 128, E3 ubiquitin protein ligase; RING-type E3 ubiquitin transferase RNF128; RP11-150F24.1; unnamed protein product
Gene Aliases: 1300002C13Rik; GRAIL; Greul1; RGD1566282
UniProt ID: (Human) Q8TEB7, (Mouse) Q9D304
Entrez Gene ID: (Horse) 100054821, (Dog) 492051, (Human) 79589, (Mouse) 66889, (Rat) 315911
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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