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Proteintech
BAG3 Polyclonal Antibody
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Product Details
10599-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Hamster,
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
BAG3 Fusion Protein Ag0956 (275-575 aa encoded by BC006418)
Conjugate
Form
Liquid
Concentration
0.48 mg/mL
Amount
72 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SREGSPARS STPLHSPSPI RVHTVVDRPQ QPMTHRETAP VSQPENKPES KPGPVGPELP PGHIPIQVIR KEVDSKPVSQ KPPPPSEKVE VKVPPAPVPC PPPSPGPSAV PSSPKSVATE ERAAPSTAPA EATPPKPGEA EAPPKHPGVL KVEAILEKVQ GLEQAVDNFE GKKTDKKYLM IEEYLTKELL ALDSVDPEGR ADVRQARRDG VRKVQTILEK LEQKAIDVPG QVQVYELQPS NLEADQPLQA IMEMGAVAAD KGKKNAGNAE DPHTETQQPE ATAAATSNPS SMTDTPGNPA AP (275-575 aa encoded by BC006418)
Target Information
BAG3 are among BAG proteins that compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BAG family molecular chaperone regulator 3; BAG-3; Bcl-2 interacting cell death suppressor; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Bcl-2-binding protein BIS transcript 2; Bcl-2-interacting death suppressor; BCL2 associated athanogene 3; BCL2-binding athanogene 3; DKFZp434E0610; Docking protein CAIR-1; MGC104307; unnamed protein product
Gene Aliases: AA407278; BAG-3; BAG3; BIS; CAIR-1; CMD1HH; CMT2JJ; HMND15; MFM6; mg638; MNCb-2243
UniProt ID: (Human) O95817, (Mouse) Q9JLV1
Entrez Gene ID: (Human) 9531, (Mouse) 29810, (Rat) 293524
apoptotic process
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of striated muscle cell apoptotic process
protein stabilization
cellular response to mechanical stimulus
extrinsic apoptotic signaling pathway in absence of ligand
autophagosome assembly
protein folding
striated muscle cell apoptotic process
spinal cord development
cellular response to heat
cellular response to unfolded protein
positive regulation of protein import into nucleus
negative regulation of apoptotic process
muscle cell cellular homeostasis
positive regulation of protein export from nucleus
chaperone-mediated autophagy
aggresome assembly
extrinsic apoptotic signaling pathway
protein transport along microtubule
negative regulation of protein targeting to mitochondrion
positive regulation of aggrephagy
brain development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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