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Proteintech
PAX8 Polyclonal Antibody
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Product Details
10336-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Bovine,
Human,
Mouse,
Rat,
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
PAX8 Fusion Protein Ag0306
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Amount
34.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can detect all 5 isoforms of PAX8 (31 kDa, 34 kDa, 41 kDa, 43 kDa, and 48 kDa). A 58-60 kDa form has also been reported. Proteintech's 10336-1-AP antibody has cross-reactivities with the other PAX family members.
Target Information
This gene encodes a member of the paired box family of transcription factors. Members of this gene family typically encode proteins that contain a paired box domain, an octapeptide, and a paired-type homeodomain. This nuclear protein is involved in thyroid follicular cell development and expression of thyroid-specific genes. Mutations in this gene have been associated with thyroid dysgenesis, thyroid follicular carcinomas and atypical follicular thyroid adenomas. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HGNC:8622; paired box gene 8; Paired box protein Pax-8; paired domain gene 8; paired-box-protein; Pax-8 protein; PAX8d; PAX8e; PAX8F; unnamed protein product
Gene Aliases: PAX-8; PAX8
UniProt ID: (Human) Q06710, (Mouse) Q00288, (Rat) P51974
Entrez Gene ID: (Human) 7849, (Mouse) 18510, (Rat) 81819
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
thyroid-stimulating hormone receptor activity
protein binding
sequence-specific double-stranded DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
sequence-specific DNA binding
transcription regulatory region DNA binding
urogenital system development
metanephros development
mesonephros development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
organ morphogenesis
cell differentiation
thyroid gland development
inner ear morphogenesis
regulation of apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
pronephros development
cellular response to gonadotropin stimulus
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
metanephric distal convoluted tubule development
metanephric nephron tubule formation
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis
regulation of metanephric nephron tubule epithelial cell differentiation
positive regulation of branching involved in ureteric bud morphogenesis
negative regulation of mesenchymal cell apoptotic process involved in metanephros development
negative regulation of apoptotic process involved in metanephric collecting duct development
negative regulation of apoptotic process involved in metanephric nephron tubule development
positive regulation of metanephric DCT cell differentiation
positive regulation of thyroid hormone generation
regulation of thyroid-stimulating hormone secretion
branching involved in ureteric bud morphogenesis
kidney development
ventricular septum development
mesenchymal to epithelial transition involved in metanephros morphogenesis
regulation of transcription from RNA polymerase II promoter
nervous system development
central nervous system development
sensory organ development
anatomical structure morphogenesis
negative regulation of cardiac muscle cell apoptotic process
epithelial cell differentiation
thyroid-stimulating hormone signaling pathway
pronephric field specification
otic vesicle development
S-shaped body morphogenesis
kidney epithelium development
mesonephric tubule development
metanephric epithelium development
metanephric comma-shaped body morphogenesis
metanephric S-shaped body morphogenesis
sulfur compound metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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