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Proteintech
TGIF2 Polyclonal Antibody
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Product Details
11522-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
TGIF2 Fusion Protein Ag2085 (1-237 aa encoded by BC012816)
Conjugate
Form
Liquid
Concentration
0.22 mg/mL
Amount
33 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSDSDLGED EGLLSLAGKR KRRGNLPKES VKILRDWLYL HRYNAYPSEQ EKLSLSGQTN LSVLQICNWF INARRRLLPD MLRKDGKDPN QFTISRRGGK ASDVALPRGS SPSVLAVSVP APTNVLSLSV CSMPLHSGQG EKPAAPFPRG ELESPKPLVT PGSTLTLLTR AEAGSPTGGL FNTPPPTPPE QDKEDFSSFQ LLVEVALQRA AEMELQKQQD PSLPLLHTPI PLVSENPQ (1-237 aa encoded by BC012816)
Target Information
The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 5'-TG-3' interacting factor 2; 5'-TG-3'-interacting factor 2; Homeobox protein TGIF2; OTTHUMP00000030849; TALE family homeobox; TGF(beta)-induced transcription factor 2; TGF-beta-induced transcription factor 2; TGFB-induced factor 2; TGFB-induced factor 2 (TALE family homeobox); transcription growth factor-beta-induced factor 2; unnamed protein product
Gene Aliases: 4921501K24; 5730599O09Rik; C80753; C81206; TGIF2
UniProt ID: (Human) Q9GZN2, (Mouse) Q8C0Y1
Entrez Gene ID: (Human) 60436, (Mouse) 228839
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific double-stranded DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
regulation of gastrulation
neuron differentiation
amacrine cell differentiation
nodal signaling pathway
retina development in camera-type eye
positive regulation of amacrine cell differentiation
transcription, DNA-templated
positive regulation of neuron differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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