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NeoBiotechnologies
14-3-3 Sigma/Stratifin Monoclonal Antibody (CPTC-SFN-2)
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Product Details
2810-MSM1-P1
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1, kappa
Class
Monoclonal
Type
Antibody
Clone
CPTC-SFN-2
Immunogen
Recombinant human full-length SFN protein
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 0.05% BSA
Contains
0.05% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.
Target Information
This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 14-3-3 protein sigma; 14-3-3sigma; Epithelial cell marker protein 1; HGNC:10773; SFN; Stratifin
Gene Aliases: HME1; SFN; YWHAS
UniProt ID: (Human) P31947
Entrez Gene ID: (Human) 2810
negative regulation of transcription from RNA polymerase II promoter
release of cytochrome c from mitochondria
keratinocyte development
negative regulation of protein kinase activity
protein export from nucleus
signal transduction
protein localization
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of epidermal cell division
negative regulation of keratinocyte proliferation
regulation of cell-cell adhesion
keratinocyte differentiation
positive regulation of cell growth
keratinization
regulation of protein localization
defense response to bacterium
skin development
keratinocyte proliferation
positive regulation of epidermal cell differentiation
positive regulation of cell adhesion
negative regulation of innate immune response
positive regulation of protein export from nucleus
cytolysis in other organism
regulation of cell cycle
establishment of skin barrier
stem cell proliferation
cAMP/PKA signal transduction
non-canonical inflammasome complex assembly
negative regulation of protein localization to plasma membrane
positive regulation of cellular protein localization
negative regulation of stem cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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