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NeoBiotechnologies

HSP60 (Heat Shock Protein 60) Recombinant Mouse Monoclonal Antibody (rHSPD1, 6497)

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HSP60 (Heat Shock Protein 60) Recombinant Mouse Monoclonal Antibody (rHSPD1, 6497)

Product Details

3329-MSM14-P1ABX

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-
Product Specifications

Species Reactivity

Bovine, Dog, Chicken, Hamster, Human, Mouse, Non-human primate, Sheep, Pig, Rabbit, Rat

Host/Isotype

Mouse / IgG1, kappa

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

rHSPD1, 6497

Immunogen

Recombinant human full-length HSP60 protein
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

Target Information

This gene encodes a member of the chaperonin family. The encoded mitochondrial protein may function as a signaling molecule in the innate immune system. This protein is essential for the folding and assembly of newly imported proteins in the mitochondria. This gene is adjacent to a related family member and the region between the 2 genes functions as a bidirectional promoter. Several pseudogenes have been associated with this gene. Two transcript variants encoding the same protein have been identified for this gene. Mutations associated with this gene cause autosomal recessive spastic paraplegia 13.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 60 kDa chaperonin; 60 kDa heat shock protein; 60 kDa heat shock protein, mitochondrial; chaperonin; chaperonin (HSP60); Chaperonin 60; CPN60; epididymis secretory sperm binding protein; heat shock 60 kDa protein 1; heat shock 60kD protein 1 (chaperonin); heat shock 60kDa protein 1; heat shock 60kDa protein 1 (chaperonin); heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_1; heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_2; heat shock 60kDa protein 1 (chaperonin) isoform HSPD1_4; Heat shock protein; heat shock protein 1 (chaperonin); Heat shock protein 60; heat shock protein 60 (liver); heat shock protein 65; Heat shock protein family D member 1; heat shock protein, 60 kDa; HSP; HSP-60; HSP-65; hsp60; Hsp60s1; HuCHA60; mitochondrial heat shock 60 kDa protein 1; Mitochondrial matrix protein P1; P1 protein; P60 lymphocyte protein; short heat shock protein 60 Hsp60s1; unnamed protein product

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Gene Aliases: 60kDa; CPN60; GROEL; HLD4; HSP-60; HSP60; HSP65; HSPD1; Hspd1-30p; HuCHA60; I79_011398; RCJMB04_7g5; SPG13

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UniProt ID: (Chicken) Q5ZL72, (Human) P10809, (Chinese hamster) P18687, (Mouse) P63038, (Rat) P63039

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Entrez Gene ID: (Dog) 478854, (Chicken) 424059, (Pig) 492279, (Human) 3329, (Sheep) 101122254, (Bovine) 511913, (Rabbit) 100349912, (Chinese hamster) 100689473, (Mouse) 15510, (Rat) 63868

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Function(s)
ATP binding isomerase activity lipopolysaccharide binding p53 binding double-stranded RNA binding protein binding high-density lipoprotein particle binding ubiquitin protein ligase binding apolipoprotein A-I binding chaperone binding nucleotide binding DNA replication origin binding single-stranded DNA binding RNA binding ATPase activity enzyme binding apolipoprotein binding unfolded protein binding cysteine-type endopeptidase activator activity ATP-dependent protein folding chaperone protease binding protein complex binding insulin binding poly(A) RNA binding protein heterodimerization activity misfolded protein binding
Process(es)
B cell cytokine production MyD88-dependent toll-like receptor signaling pathway positive regulation of T cell mediated immune response to tumor cell protein folding activation of cysteine-type endopeptidase activity involved in apoptotic process apoptotic mitochondrial changes response to cold positive regulation of interferon-alpha production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-6 production mitochondrial unfolded protein response protein refolding B cell proliferation T cell activation positive regulation of macrophage activation negative regulation of apoptotic process protein import into mitochondrial intermembrane space isotype switching to IgG isotypes protein stabilization positive regulation of T cell activation interaction with symbiont cellular response to interleukin-7 positive regulation of cytokine production 'de novo' protein folding response to unfolded protein B cell activation adhesion of symbiont to host chaperone-mediated protein complex assembly protein maturation negative regulation of execution phase of apoptosis positive regulation of execution phase of apoptosis detection of misfolded protein positive regulation of apoptotic process negative regulation of neuron apoptotic process positive regulation of inflammatory response chaperone mediated protein folding requiring cofactor response to hypoxia response to heat response to organic substance response to organic cyclic compound response to lipopolysaccharide response to ATP response to cocaine response to drug response to hydrogen peroxide response to estrogen
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