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Bethyl Laboratories
DDX20 Polyclonal Antibody
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Product Details
IHC-00449
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 600 and 650 of human DEAD (Asp-Glu-Ala-Asp) Box 20.
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Horse, Pig, Panda, Orangutan, Monkey, Gorilla, Chimpanzee, hirteen-lined ground squirrel and Small-eared galago
Target Information
Gemin 3 is a member of the DEAD box protein family which are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD) and are putative RNA helicases. DEAD box proteins such as Gemin 3 are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of DEAD box family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Gemin 3 has an ATPase activity and a component of the survival of motor neurons (SMN) complex. The Gemin 3 protein may play a catalytic role in the function of the SMN complex on RNPs. Diseases associated with Gemin 3 protein dysfunction include spinal muscular dystrophy and muscular atrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Component of gems 3; DDX 20; DEAD (Asp-Glu-Ala-Asp) box polypeptide 20; DEAD box protein 20; DEAD box protein DP 103; DEAD-box protein DP103; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 20, 103kD; DEAD/H BOX 20; DKFZP434H052; DP 103; dp103; Gemin-3; Probable ATP-dependent RNA helicase DDX20; similar to Homo sapiens mRNA; cDNA DKFZp43H052 (from clone DKFZp434H052) with GenBank Accession AL133598.1; SMN-interacting protein; unnamed protein product
Gene Aliases: DDX20; DP103; GEMIN3
UniProt ID: (Human) Q9UHI6
Entrez Gene ID: (Human) 11218
nucleotide binding
nucleic acid binding
DNA binding
RNA helicase activity
mRNA binding
helicase activity
protein binding
ATP binding
hydrolase activity
ATPase activity
nucleoside-triphosphatase activity
protein domain specific binding
protein binding, bridging
histone deacetylase binding
DNA-binding transcription factor binding
negative regulation of transcription from RNA polymerase II promoter
spliceosomal tri-snRNP complex assembly
spliceosomal snRNP assembly
RNA processing
mRNA processing
negative regulation of cell proliferation
RNA splicing
positive regulation of apoptotic process
negative regulation of transcription, DNA-templated
oogenesis
regulation of steroid biosynthetic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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