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Invitrogen
NUP107 Monoclonal Antibody (39C7)
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FIGURE: 1 / 10
NUP107 Antibody (MA1-10031) in ICC/IF
Immunofluorescence analysis of NUP107 was performed using 70% confluent log phase PC-3 cells. The cells were fixed with 4% Paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 10 minutes, and blocked with 2% BSA for 10 minutes at room temperature. The cells were labeled with NUP107 Monoclonal Antibody (39C7) (Product # MA1-10031) at 1:100 dilution in 0.1% BSA, incubated at 4 degree celsius overnight and then labeled with Goat anti-Mouse IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488 (Product ... View More
Product Details
MA1-10031
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Bovine,
Chicken,
Fruit fly,
Horse,
Human,
Mouse,
Pig,
Rat,
Yeast
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
39C7
Immunogen
Yeast nuclear preparation.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
tissue culture supernatant
Contains
5mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
For immunofluorescence on yeast cells, try MCA-39C7 diluted 1:100 to 1:500. For immunofluorescence on mammalian cells try at 1:50 to 1:100.
Target Information
The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p. While the majority of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells in association with proteins such as Mad1, Mad2, Bub3 and Cdc20. Immunodepletion of the NUP107-160 complex resulted in defective spindle assembly indicating that it has multiple functions. NUP107 has recently been identified as an HIV dependency factor (HDF), suggesting that NUP107 may be an important drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 107 kDa nucleoporin; CG6743-PA; nuclear pore complex; Nuclear pore complex protein Nup107; Nuclear pore complex protein Nup107-like protein; Nuclear pore protein nup107; nucleoporin 107; nucleoporin 107kDa; Nucleoporin Nup107; Nup107-PA; Nup170; p105; unnamed protein product
Gene Aliases: AW541137; BcDNA:LD18761; C76801; CG6743; Dmel\CG6743; Dmel_CG6743; dmNup107; GAMOS7; NPHS11; Nup; Nup 107; NUP107; Nup170; NUP84; ODG6; ODG6; GAMOS7; SPBC428.01c; SPBC582.11c
UniProt ID: (Human) P57740, (Fruit fly) Q9V466, (Mouse) Q8BH74, (Fission yeast) Q10331
posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
mRNA export from nucleus
protein import into nucleus
nucleocytoplasmic transport
female gonad development
protein transport
mRNA transport
nuclear pore complex assembly
nephron development
double-strand break repair via homologous recombination
regulation of transcription, DNA-templated
meiosis I cytokinesis
male meiosis cytokinesis
eggshell formation
regulation of nucleocytoplasmic transport
spermatocyte division
positive regulation of protein localization to nucleus
transmembrane transport
transport
rRNA export from nucleus
poly(A)+ mRNA export from nucleus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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