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Invitrogen
Cathepsin L Monoclonal Antibody (33/2)
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FIGURE: 1 / 5
Cathepsin L Antibody (MA1-26774) in WB
Western blot was performed using Anti-Cathepsin L Monoclonal Antibody (33/2)(Product # MA1-26774) and a 25kDa band corresponding to the mature form of Cathepsin L was observed across cell lines and tissue extracts tested. An additional faint bands around 41kDa which corresponds to the Procathepsin L and 31kDa which also corresponds to the mature form of Cathepsin L was observed in A549. Whole cell extracts (30 µg lysate) of A549 (Lane 1), Hep G2 (Lane 2), MCF 10A (Lane 3) and tissue extracts of Mouse Kidney (Lane 4) and Mouse Liver (Lane 5... View More
Product Details
MA1-26774
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mink,
Mouse,
Rat
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
33/2
Immunogen
Procathepsin L isolated from the human lung cancer cell line EPLC 32M1.
Conjugate
Form
Liquid
Concentration
4.3 mg/mL
Amount
430 µg
Storage buffer
Ascites
Contains
15mM sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: mink lung cell.
Target Information
The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alternatively spliced; Cat L; Cathepsin L1; CP-2; CTSL; Cyclic protein 2; furless; hCATL AIII; lysosomal cysteine protease; Major excreted protein; MEP; nackt; p39 cysteine proteinase; Procathepsin L; unnamed protein product
Gene Aliases: 1190035F06Rik; CATHL; CATL; CTSL; CTSL1; fs; MEP; nkt
UniProt ID: (Human) P07711, (Mouse) P06797, (Rat) P07154
Entrez Gene ID: (Human) 1514, (Mouse) 13039, (Rat) 25697
fibronectin binding
cysteine-type endopeptidase activity
protein binding
collagen binding
peptidase activity
cysteine-type peptidase activity
hydrolase activity
histone binding
proteoglycan binding
serpin family protein binding
aminopeptidase activity
cysteine-type carboxypeptidase activity
kininogen binding
protein complex binding
peptide binding
cysteine protease
adaptive immune response
proteolysis
protein autoprocessing
fusion of virus membrane with host plasma membrane
receptor-mediated endocytosis of virus by host cell
antigen processing and presentation
antigen processing and presentation of exogenous peptide antigen via MHC class II
collagen catabolic process
zymogen activation
enkephalin processing
fusion of virus membrane with host endosome membrane
CD4-positive, alpha-beta T cell lineage commitment
viral entry into host cell
antigen processing and presentation of peptide antigen
proteolysis involved in cellular protein catabolic process
elastin catabolic process
macrophage apoptotic process
cellular response to thyroid hormone stimulus
cell communication
negative regulation of keratinocyte proliferation
protein processing
hair follicle morphogenesis
catagen
decidualization
epithelial tube branching involved in lung morphogenesis
regulation of actin cytoskeleton reorganization
spermatogenesis
male gonad development
cellular response to starvation
response to glucose
multicellular organism aging
response to organic cyclic compound
nerve development
response to gonadotropin
autophagic cell death
response to glucocorticoid
Sertoli cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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