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Invitrogen
cGKI Monoclonal Antibody (T.344.1)
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Product Details
MA5-14862
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
T.344.1
Immunogen
Synthetic peptide corresponding to cental residues of human PKG-1
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with PKG-2.
Target Information
PRKG1 is a cGMP-dependent serine/threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cGK 1; cGK cGK cGKI; cGK cGK1; cGK1; cGKI; cGMP dependent protein kinase type 1; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; OTTHUMP00000019618; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type I; RP11-346D6.1; unnamed protein product
Gene Aliases: AAT8; AW125416; cGK; cGK 1; cGK1; CGKI; cGKI-alpha; cGKI-BETA; Gm19690; PKG; PKG1; Pkgi; PRKG1; PRKG1B; PRKGR1A; PRKGR1B
UniProt ID: (Human) Q13976, (Mouse) P0C605
Entrez Gene ID: (Human) 5592, (Mouse) 19091, (Rat) 54286
nucleotide binding
catalytic activity
protein kinase activity
protein serine/threonine kinase activity
cGMP-dependent protein kinase activity
calcium channel regulator activity
protein binding
ATP binding
kinase activity
transferase activity
cGMP binding
identical protein binding
mitogen-activated protein kinase p38 binding
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
protein homodimerization activity
non-receptor serine/threonine protein kinase
neuron migration
protein phosphorylation
signal transduction
positive regulation of cytosolic calcium ion concentration
spermatid development
heart development
negative regulation of inositol phosphate biosynthetic process
negative regulation of glutamate secretion
negative regulation of smooth muscle cell migration
dendrite development
cGMP-mediated signaling
cerebellum development
actin cytoskeleton organization
forebrain development
vasodilation
positive regulation of circadian rhythm
regulation of GTPase activity
regulation of vascular permeability
negative regulation of smooth muscle contraction
collateral sprouting
relaxation of vascular smooth muscle
cell growth involved in cardiac muscle cell development
negative regulation of platelet aggregation
bone growth
negative regulation of vascular smooth muscle cell proliferation
negative regulation of vascular associated smooth muscle cell migration
regulation of testosterone biosynthetic process
metabolic process
phosphorylation
negative regulation of heart contraction
positive regulation of vasodilation
mitophagy in response to mitochondrial depolarization
positive regulation of large conductance calcium-activated potassium channel activity
brain development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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