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Invitrogen
Jagged1 Monoclonal Antibody (J.841.5)
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Product Details
MA5-15012
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
J.841.5
Immunogen
Synthetic peptide corresponding to residues surrounding Glu1140 (intracellular region) of human Jagged1
Conjugate
Form
Liquid
Concentration
78 µg/mL
Amount
7.8 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
It is not recommended to aliquot this antibody.
This antibody is not cross-reactive with Jagged2.
Target Information
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD339; jagged canonical Notch ligand 1; Jagged1; Protein jagged-1; putative; Serrate-1; unnamed protein product
Gene Aliases: ABE2; AGS; AGS1; AHD; AWS; CD339; CMT2HH; DCHE; Gsfabe2; HJ1; Htu; JAG1; JAGL1; Ozz; Ser-1
UniProt ID: (Human) P78504, (Mouse) Q9QXX0
Entrez Gene ID: (Human) 182, (Mouse) 16449
angiogenesis
cell fate determination
negative regulation of cell-matrix adhesion
blood vessel remodeling
morphogenesis of an epithelial sheet
inhibition of neuroepithelial cell differentiation
T cell mediated immunity
aortic valve morphogenesis
pulmonary valve morphogenesis
cardiac right ventricle morphogenesis
cell communication
Notch signaling pathway
nervous system development
organ morphogenesis
regulation of gene expression
positive regulation of macromolecule biosynthetic process
negative regulation of cell-cell adhesion
hemopoiesis
neuron differentiation
keratinocyte differentiation
negative regulation of cell migration
response to muramyl dipeptide
aorta morphogenesis
regulation of cell proliferation
auditory receptor cell differentiation
camera-type eye development
myoblast differentiation
endothelial cell differentiation
negative regulation of cell differentiation
negative regulation of fat cell differentiation
negative regulation of endothelial cell differentiation
positive regulation of myeloid cell differentiation
negative regulation of neuron differentiation
positive regulation of osteoblast differentiation
positive regulation of Notch signaling pathway
positive regulation of transcription from RNA polymerase II promoter
animal organ development
system development
inner ear development
regulation of epithelial cell proliferation
cardiac septum morphogenesis
ciliary body morphogenesis
neuroendocrine cell differentiation
pulmonary artery morphogenesis
cardiac neural crest cell development involved in outflow tract morphogenesis
endocardial cushion cell development
positive regulation of cardiac epithelial to mesenchymal transition
nephron development
glomerular visceral epithelial cell development
distal tubule development
loop of Henle development
neuronal stem cell population maintenance
negative regulation of stem cell differentiation
multicellular organism development
Notch signaling involved in heart development
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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