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Invitrogen
HAS2 Monoclonal Antibody (4E7)
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Product Details
MA5-17087
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4E7
Immunogen
Purified recombinant fragment of human HAS2 (amino acids: 67-170) expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
MA5-17087 targets HAS2 in indirect ELISA, ICC, IHC, IF and WB applications and shows reactivity with Human samples.
The MA5-17087 immunogen is purified recombinant fragment of human HAS2 (amino acids: 67-170) expressed in E. Coli.
MA5-17087 detects HAS2 which has a predicted molecular weight of approximately 63.5kDa.
Target Information
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HA synthase 2; Hyaluronan synthase 2; Hyaluronate synthase 2; Hyaluronic acid synthase 2; unnamed protein product
Gene Aliases: HAS2
UniProt ID: (Human) Q92819
Entrez Gene ID: (Human) 3037
polysaccharide biosynthetic process
vasculogenesis
kidney development
glycosaminoglycan biosynthetic process
positive regulation of cell proliferation
positive regulation of keratinocyte proliferation
positive regulation of smooth muscle cell migration
hyaluronan metabolic process
hyaluronan biosynthetic process
positive regulation of cell migration
positive regulation of urine volume
cellular response to platelet-derived growth factor stimulus
atrioventricular canal development
estrous cycle
positive regulation of keratinocyte migration
bone morphogenesis
renal water absorption
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to fluid shear stress
extracellular matrix assembly
endocardial cushion to mesenchymal transition
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of hyaluronan biosynthetic process
positive regulation of monocyte aggregation
regulation of extracellular matrix assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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