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Invitrogen
ECE1 Monoclonal Antibody (303913)
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FIGURE: 1 / 1
ECE1 Antibody (MA5-24016) in Flow
Flow cytometry of ECE1 in MCF-7 human breast cancer cell line. Samples were incubated in ECE1 monoclonal antibody (Product # MA5-24016) or isotype control antibody followed by Allophycocyanin-conjugated Anti-Rat IgG F(ab)2 Secondary Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin.
Product Details
MA5-24016
Product Specifications
Species Reactivity
Human
Host/Isotype
Rat
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
303913
Immunogen
Mouse myeloma cell line NS0-derived recombinant human ECE-1 Gln90-Trp770
Conjugate
Form
Lyophilized
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Protein A/G
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
Endothelin-converting enzyme 1 (ECE1) is located on chromosome 1p36.12 and encodes a zinc metalloprotease involved in the maturation of endothelin peptides, which are critical for vascular tone regulation and blood pressure control. ECE1 processes precursor proteins into active endothelins, particularly endothelin-1, the most potent vasoconstrictor known. This enzyme is expressed in multiple tissues, including endothelial cells, smooth muscle cells, and the central nervous system, where it participates in diverse physiological processes such as vasoconstriction, cell proliferation, and hormone secretion. Beyond its cardiovascular functions, ECE1 is implicated in neural development and neural crest cell migration. Dysregulation of ECE1 activity or endothelin signaling is associated with several pathologies, including hypertension, heart failure, and cancer progression due to its role in controlling vascular dynamics. Research into ECE1 aims to explore its therapeutic potential in managing cardiovascular disorders and its broader implications in systemic pathophysiology.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ECE 1; ECE-1; Endothelin-converting enzyme 1; unnamed protein product
Gene Aliases: ECE; ECE1
UniProt ID: (Human) P42892
Entrez Gene ID: (Human) 1889
positive regulation of receptor recycling
regulation of systemic arterial blood pressure by endothelin
proteolysis
signal transduction
G-protein coupled receptor signaling pathway
axon guidance
heart development
anatomical structure morphogenesis
gene expression
substance P catabolic process
bradykinin catabolic process
calcitonin catabolic process
protein processing
peptide hormone processing
regulation of vasoconstriction
neuron projection development
endothelin maturation
embryonic heart tube development
hormone catabolic process
embryonic digit morphogenesis
ear development
pharyngeal system development
axonogenesis involved in innervation
sympathetic neuron axon guidance
semaphorin-plexin signaling pathway involved in axon guidance
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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