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Invitrogen
ACBD3 Monoclonal Antibody (OTI5F9)
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FIGURE: 1 / 13
ACBD3 Antibody (MA5-25999) in IHC (P)
Immunohistochemistry was performed on paraffin-embedded adenocarcinoma of human endometrium tissue. To expose target proteins, 10mM citric buffer, pH6.0, 100°C for 10min was used. Following antigen retrieval, tissues were probed with a ACBD3 monoclonal antibody (Product # MA5-25999).
Product Details
MA5-25999
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5F9
Immunogen
Full length human recombinant protein of ACBD3 produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
GOLPH1, also known as GCP60, was initially identified as a Golgi protein that can interact with the integral membrane protein giantin and is thought to be involved in the maintenance of the Golgi structure. GOLPH1 has also been shown to interact with other Golgi proteins such as Golgin-160, a Golgi protein that can be cleaved by caspases-2, -3, and -7, leading to the nuclear localization of Golgin-160. GOLPH1 interaction with the Golgin-160 fragments is stronger than that with the intact Golgin-160, with its interaction regulated by the oxidation state of Cys-463 within GOLPH1, suggesting that the nuclear localization of the caspase-cleaved Golgin-160 fragments is a highly coordinated event. GOLPH1 has also been found to interact with Numb, a cytosolic signaling protein that mediates asymetric cell division of neural progenitor cells to a daughter progenitor cell and a neuron, suggesting that Golgi fragmentation and reconstitution during the cell cycle differentially regulate Numb signaling through changes in GOLPH1 subcellular distribution and may couple cell fate with cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Acyl-CoA-binding domain-containing protein 3; acyl-Coenzyme A binding domain containing 3; GOCAP1; golgi complex associated protein 1, 60kDa; Golgi complex-associated protein 1; Golgi phosphoprotein 1; Golgi resident protein GCP60; GOLPH1; PAP7; PBR associated protein; PBR- and PKA-associated protein 7; Peripheral benzodiazepine receptor-associated protein PAP7; PKA (RIalpha)-associated protein; unnamed protein product
Gene Aliases: ACBD3; GCP60; GOCAP1; GOLPH1; PAP7
UniProt ID: (Human) Q9H3P7
Entrez Gene ID: (Human) 64746
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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