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Invitrogen
JPH2 Monoclonal Antibody (OTI2D3)
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Product Details
MA5-26300
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
OTI2D3
Immunogen
Full length human recombinant protein of JPH2 produced in HEK293T cell
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: JP-2; Junctophilin type 2; Junctophilin-2; unnamed protein product
Gene Aliases: CMD2E; CMH17; JP-2; JP2; JPH2
UniProt ID: (Human) Q9BR39
Entrez Gene ID: (Human) 57158
core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
phosphatidylserine binding
DNA binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
phosphatidylinositol-3,4,5-trisphosphate binding
phosphatidylinositol-5-phosphate binding
phosphatidylinositol-3-phosphate binding
phosphatidylinositol-4-phosphate binding
phosphatidic acid binding
phosphatidylinositol-3,5-bisphosphate binding
negative regulation of transcription from RNA polymerase II promoter
positive regulation of cytosolic calcium ion concentration
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by calcium ion signaling
negative regulation of transcription, DNA-templated
regulation of cardiac muscle tissue development
calcium ion homeostasis
positive regulation of ryanodine-sensitive calcium-release channel activity
calcium ion transport into cytosol
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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