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Invitrogen
Angiopoietin 1 Recombinant Rabbit Monoclonal Antibody (6C4S7)
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FIGURE: 1 / 2
Angiopoietin 1 Antibody (MA5-35399) in IHC (P)
Immunohistochemistry analysis of Angiopoietin 1 in paraffin-embedded human colon. Samples were incubated with Angiopoietin 1 Monoclonal antibody (Product # MA5-35399) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
MA5-35399
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
6C4S7
Immunogen
Synthetic peptide
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: EMEGKHKEEL DTLKEEKENL QGLVTRQTYI IQELEKQLNR ATTNNSVLQK QQLELMDTVH NLVNLCTKEG VLLKGGKREE EKPFRDCADV YQAGFNKSGI Y
Target Information
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANG-1; Angiopoietin-1; KIAA0003; ligand for the TIE2 receptor; unnamed protein product
Gene Aliases: 1110046O21Rik; AGP1; AGPT; AGPT-1; Agpt1; Ang-1; ANG1; ANGPT1; HAE5; KIAA0003
UniProt ID: (Human) Q15389, (Mouse) O08538, (Rat) O35460
Entrez Gene ID: (Human) 284, (Mouse) 11600, (Rat) 89807
angiogenesis
blood vessel development
in utero embryonic development
regulation of endothelial cell proliferation
sprouting angiogenesis
positive regulation of receptor internalization
negative regulation of cytokine production involved in immune response
negative regulation of cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
activation of transmembrane receptor protein tyrosine kinase activity
blood coagulation
positive regulation of endothelial cell migration
positive regulation of gene expression
regulation of skeletal muscle satellite cell proliferation
hemopoiesis
cell differentiation
negative regulation of blood coagulation
heparin biosynthetic process
positive regulation of protein ubiquitination
cell-substrate adhesion
regulation of tumor necrosis factor production
protein localization to cell surface
negative regulation of protein import into nucleus
negative regulation of apoptotic process
negative regulation of vascular permeability
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron apoptotic process
positive regulation of blood vessel endothelial cell migration
positive regulation of cell adhesion
Tie signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of coagulation
positive chemotaxis
positive regulation of multicellular organismal process
neuron apoptotic process
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
glomerulus vasculature development
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of maintenance of permeability of blood-brain barrier
negative regulation of endothelial cell apoptotic process
regulation of macrophage migration inhibitory factor signaling pathway
ovarian follicle development
patterning of blood vessels
vasculogenesis
negative regulation of protein phosphorylation
negative regulation of cytokine secretion involved in immune response
endocardium morphogenesis
multicellular organism development
endoderm development
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of peptidyl-serine phosphorylation
regulation of protein binding
protein homooligomerization
cardiac muscle tissue morphogenesis
vasculogenesis involved in coronary vascular morphogenesis
response to hypoxia
organ regeneration
response to vitamin B3
response to estrogen
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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