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Invitrogen
USP22 Recombinant Rabbit Monoclonal Antibody (9C7I8)
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FIGURE: 1 / 3
USP22 Antibody (MA5-35788) in WB
Western blot analysis of USP22 in extracts of Mouse thymus. Samples were incubated with USP22 Monoclonal antibody (Product # MA5-35788) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Product Details
MA5-35788
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
9C7I8
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human USP22 (Q9UPT9)
Conjugate
Form
Liquid
Concentration
0.84 mg/mL
Amount
84 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MVSRPEPEGE AMDAELAVAP PGCSHLGSFK VDNWKQNLRA IYQCFVWSGT AEARKRKAKS CICHVCGVHL NRLHSCLYCV FFGCFTKKHI HEHAKAKRHN LAIDLMYGGI YCFLCQDYIY DKDMEIIAKE EQRKAWKMQG VGEKFSTWEP TKRELELLKH NPKRRKITSN CTIGL
Target Information
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Deubiquitinating enzyme 22; Ubiquitin carboxyl-terminal hydrolase 22; ubiquitin specific protease 22; Ubiquitin thioesterase 22; ubiquitin thiolesterase 22; ubiquitin-specific processing protease 22; Ubiquitin-specific-processing protease 22
Gene Aliases: AI427806; KIAA1063; USP22; USP3L
UniProt ID: (Human) Q9UPT9, (Mouse) Q5DU02
Entrez Gene ID: (Human) 23326, (Mouse) 216825
transcription coactivator activity
thiol-dependent ubiquitin-specific protease activity
protein binding
peptidase activity
cysteine-type peptidase activity
zinc ion binding
H4 histone acetyltransferase activity
hydrolase activity
enzyme binding
metal ion binding
histone H2B deubiquitinase activity
histone H2A deubiquitinase activity
cysteine-type endopeptidase activity
ligand-dependent nuclear receptor transcription coactivator activity
thiol-dependent ubiquitinyl hydrolase activity
cysteine protease
G2/M transition of mitotic cell cycle
regulation of DNA repair
chromatin organization
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
proteolysis
embryo development ending in birth or egg hatching
protein deubiquitination
positive regulation of type I interferon production
regulation of RNA splicing
positive regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
transcription, DNA-templated
regulation of transcription, DNA-templated
ubiquitin-dependent protein catabolic process
cell cycle
chromatin modification
histone ubiquitination
histone deubiquitination
proteasome-mediated ubiquitin-dependent protein catabolic process
histone H4 acetylation
regulation of proteasomal protein catabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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