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Invitrogen
PPAR gamma Monoclonal Antibody (C5)
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Product Details
MA5-41659
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
C5
Immunogen
Recombinant protein Peroxisome Proliferator Activated Receptor Gamma. The antigen corresponds to amino acid range 311-493 of the target protein.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
200 µg
Purification
Protein A/G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HUMPPARG; Nuclear receptor subfamily 1 group C member 3; OTTHUMP00000185032; OTTHUMP00000185036; peroxisome proliferator; peroxisome proliferator activated receptor; peroxisome proliferator activated receptor gamma; peroxisome proliferator activator receptor, gamma; Peroxisome proliferator-activated receptor gamma; PPAR gamma; PPAR-gamma; PPARy
Gene Aliases: Nr1c3; Pparg
UniProt ID: (Rat) O88275
Entrez Gene ID: (Rat) 25664
RNA polymerase II regulatory region DNA binding
core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
drug binding
zinc ion binding
enzyme binding
protein phosphatase binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
activating transcription factor binding
sequence-specific DNA binding
transcription regulatory region DNA binding
retinoid X receptor binding
arachidonic acid binding
alpha-actinin binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
negative regulation of cytokine production
placenta development
negative regulation of acute inflammatory response
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
fatty acid metabolic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
signal transduction
heart development
regulation of blood pressure
negative regulation of cell proliferation
response to cold
response to light stimulus
response to mechanical stimulus
response to organic substance
negative regulation of macrophage derived foam cell differentiation
negative regulation of receptor biosynthetic process
negative regulation of cholesterol storage
negative regulation of sequestering of triglyceride
response to organic cyclic compound
long-chain fatty acid transport
regulation of lipid metabolic process
fatty acid oxidation
monocyte differentiation
negative regulation of cell growth
epithelial cell differentiation
response to caffeine
organ regeneration
response to food
response to retinoic acid
cellular response to insulin stimulus
negative regulation of collagen biosynthetic process
response to vitamin A
response to lipid
peroxisome proliferator activated receptor signaling pathway
response to immobilization stress
response to diuretic
response to drug
glucose homeostasis
response to starvation
regulation of circadian rhythm
lipoprotein transport
positive regulation of apoptotic process
steroid hormone mediated signaling pathway
response to estrogen
cell fate commitment
fat cell differentiation
regulation of fat cell differentiation
positive regulation of fat cell differentiation
low-density lipoprotein particle receptor biosynthetic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
cell maturation
rhythmic process
negative regulation of smooth muscle cell proliferation
positive regulation of oligodendrocyte differentiation
white fat cell differentiation
brown fat cell differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
negative regulation of telomerase activity
response to low-density lipoprotein particle
positive regulation of phagocytosis, engulfment
negative regulation of interferon-gamma-mediated signaling pathway
regulation of transcription involved in cell fate commitment
cellular response to lithium ion
cellular response to retinoic acid
cellular response to vitamin E
cellular response to prostaglandin stimulus
cellular response to prostaglandin E stimulus
cellular response to organic cyclic compound
cellular response to hyperoxia
negative regulation of peptide hormone secretion
negative regulation of cellular response to insulin stimulus
response to metformin
negative regulation of pancreatic stellate cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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