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Invitrogen

CHOP Monoclonal Antibody (K49008_20C12)

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CHOP Monoclonal Antibody (K49008_20C12)

Product Details

MA5-55912

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

K49008_20C12

Immunogen

Recombinant human DDIT3 (immunogen range is 1-169).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

50 µg

Purification

Protein A

Storage buffer

PBS with 50% glycerol, 0.5% BSA

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_3668144

Product Specific Information

Sequence of this protein is as follows: MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA

Target Information

GADD153 is a small nuclear protein that is capable of dimerizing with transcription factors C/EBP alpha and beta. Once dimerized, this complex inhibits the normal binding and function of C/EBP to classical binding sites. Inversely, the C/EBP GADD153 dimer gains binding activity to other non classical C/EBP stress related targets. Under normal cellular conditions this protein is not expressed in detectable levels, but is highly unregulated during times of cellular/ER stress. Examples of GADD153 inducing stress include: treatment with tunicamycin, nutrient starvation and reducing agents that interfere with the calcium flux across the ER membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alternative DDIT3 protein; C/EBP zeta; C/EBP-homologous protein; C/EBP-homologous protein 10; CCAAT/enhancer-binding protein homologous protein; CHOP; CHOP-10; DDIT-3; DNA damage-inducible transcript 3 protein; Growth arrest and DNA damage-inducible protein GADD153; MGC4154; unnamed protein product

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Gene Aliases: AltDDIT3; C/EBPzeta; CEBPZ; CHOP; CHOP-10; CHOP10; DDIT3; GADD153

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UniProt ID: (Human) P35638

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Entrez Gene ID: (Human) 1649

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding cAMP response element binding protein binding identical protein binding protein homodimerization activity leucine zipper domain binding protein heterodimerization activity RNA polymerase II sequence-specific DNA binding transcription factor binding transcription regulator inhibitor activity transcription regulator activator activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter blood vessel maturation diaphragm contraction regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process cellular response to DNA damage stimulus ER overload response response to unfolded protein sensory perception of sound response to wounding anterior/posterior axis specification gene expression regulation of autophagy Wnt signaling pathway endoplasmic reticulum unfolded protein response negative regulation of interferon-gamma production negative regulation of interleukin-17 production negative regulation of interleukin-4 production positive regulation of interleukin-8 production response to endoplasmic reticulum stress response to platelet-derived growth factor PERK-mediated unfolded protein response ATF6-mediated unfolded protein response response to starvation proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of neuron apoptotic process cell redox homeostasis negative regulation of fat cell differentiation negative regulation of myoblast differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of sequence-specific DNA binding transcription factor activity release of sequestered calcium ion into cytosol regulation of cell cycle negative regulation of protein kinase B signaling artery development response to caloric restriction intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress calcium ion import establishment of protein localization to mitochondrion negative regulation of canonical Wnt signaling pathway negative regulation of cold-induced thermogenesis integrated stress response signaling HRI-mediated signaling GDF15-GFRAL signaling pathway positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway vascular associated smooth muscle cell migration intrinsic apoptotic signaling pathway in response to nitrosative stress vascular associated smooth muscle cell proliferation negative regulation of determination of dorsal identity positive regulation of intrinsic apoptotic signaling pathway
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