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Invitrogen
MTGR1 Polyclonal Antibody
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Product Details
PA5-100425
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human CBFA2T2(Accession O43439), corresponding to amino acid residues R259-N309.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total CBFA2T2.
Target Information
Myeloid tumor related gene (MTGR1) is found deleted in acute myeloid leukemia. Overexpression of MTGR1 can stimulate AML1-MTG8 to induce GCSF- dependent proliferation of L-G cells and to interfere with AML1- dependent transcription. AML1/MTG8 functions as a complex with MTGR1 and that the complex might be important in promoting leukemogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CBFA2/RUNX1 translocation partner 2; CBFA2T2 identified gene homolog; core-binding factor runt domain alpha subunit 2 translocated to 2 homolog; core-binding factor, runt domain, alpha subunit 2, translocated to, 2 homolog; core-binding factor, runt domain, alpha subunit 2; translocated to, 2; DKFZp313F2116; ETO homolog on chromosome 20; ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; myeloid translocation gene-related protein 1; Myeloid translocation-related protein 1; p85; Protein CBFA2T2; RP5-1137F22.1; translocated to, 2; unnamed protein product; ZMYND3 CBFA2T2
Gene Aliases: A430091M07; C330013D05Rik; CBFA2T2; Cbfa2t2h; EHT; MTGR1; p85; ZMYND3
UniProt ID: (Human) O43439, (Mouse) O70374
Entrez Gene ID: (Human) 9139, (Rat) 296293, (Mouse) 12396
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
positive regulation of neuron projection development
negative regulation of neuron projection development
epithelial cell differentiation
negative regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
intestinal epithelial cell differentiation
positive regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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