Search
Invitrogen
alpha Actinin 1/2/3/4 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-103181
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ACTN1(Accession P12814), corresponding to amino acid residues Q167-D217.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total ACTN1/2/3/4.
Target Information
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: actinin 1 smooth muscle; alpha actinin 1a; alpha actinin 4; Alpha-actinin cytoskeletal isoform; alpha-actinin skeletal muscle; Alpha-actinin skeletal muscle isoform 2; Alpha-actinin skeletal muscle isoform 3; Alpha-actinin-1; Alpha-actinin-2; Alpha-actinin-3; Alpha-actinin-4; epididymis secretory sperm binding protein; F-actin cross-linking protein; focal segmental glomerulosclerosis 1; non-muscle alpha-actinin 1; Non-muscle alpha-actinin 4; Non-muscle alpha-actinin-1; transcriptional coactivator; unnamed protein product
Gene Aliases: 1110008F24Rik; 3110023F10Rik; ACTININ-4; ACTN1; Actn1a; ACTN2; ACTN3; ACTN3D; ACTN4; BDPLT15; C77391; CMD1AA; CMH23; CMYO8; CMYP8; FSGS; FSGS1; MPD6; MYOCOZ
UniProt ID: (Human) P12814, (Human) P35609, (Human) Q08043, (Human) O43707, (Rat) Q9Z1P2, (Mouse) Q7TPR4, (Mouse) Q9JI91, (Mouse) O88990, (Mouse) P57780, (Rat) Q9QXQ0
Entrez Gene ID: (Human) 87, (Human) 88, (Human) 89, (Human) 81, (Rat) 81634, (Mouse) 109711, (Mouse) 11472, (Rat) 291245, (Mouse) 11474, (Rat) 171009, (Mouse) 60595, (Rat) 63836
transcription coactivator activity
double-stranded RNA binding
actin binding
integrin binding
calcium ion binding
protein binding
cytoskeletal protein binding
vinculin binding
identical protein binding
protein homodimerization activity
ion channel binding
metal ion binding
actin filament binding
structural constituent of postsynapse
phosphatidylinositol-4,5-bisphosphate binding
structural constituent of muscle
protein domain specific binding
LIM domain binding
titin binding
FATZ binding
titin Z domain binding
structural constituent of postsynaptic actin cytoskeleton
channel activator activity
RNA polymerase II regulatory region sequence-specific DNA binding
nucleoside binding
RNA binding
ligand-dependent nuclear receptor binding
chromatin DNA binding
retinoic acid receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
thyroid hormone receptor coactivator activity
protein binding, bridging
protein dimerization activity
protein complex binding
nuclear hormone receptor binding
poly(A) RNA binding
protein N-terminus binding
regulation of the force of skeletal muscle contraction
skeletal muscle atrophy
transition between fast and slow fiber
response to denervation involved in regulation of muscle adaptation
actin cytoskeleton organization
positive regulation of fast-twitch skeletal muscle fiber contraction
regulation of apoptotic process
negative regulation of glycolytic process
focal adhesion assembly
positive regulation of skeletal muscle tissue growth
positive regulation of skeletal muscle fiber development
muscle cell development
bone morphogenesis
negative regulation of calcineurin-NFAT signaling cascade
regulation of muscle system process
negative regulation of oxidative phosphorylation
negative regulation of cold-induced thermogenesis
positive regulation of bone mineralization involved in bone maturation
negative regulation of relaxation of muscle
regulation of aerobic respiration
positive regulation of glucose catabolic process to lactate via pyruvate
actin filament bundle assembly
negative regulation of cellular component movement
actin crosslink formation
regulation of nucleic acid-templated transcription
cortical cytoskeleton organization
muscle contraction
microspike assembly
regulation of membrane potential
negative regulation of potassium ion transport
positive regulation of potassium ion transport
protein homotetramerization
negative regulation of potassium ion transmembrane transporter activity
positive regulation of potassium ion transmembrane transporter activity
negative regulation of protein localization to cell surface
positive regulation of receptor activity
transport
protein transport
peroxisome proliferator activated receptor signaling pathway
retinoic acid receptor signaling pathway
positive regulation of pinocytosis
positive regulation of cellular component movement
bicellular tight junction assembly
protein localization to bicellular tight junction
cell adhesion
sarcomere organization
positive regulation of transcription, DNA-templated
anatomical structure formation involved in morphogenesis
actin filament uncapping
cardiac muscle cell development
protein localization to plasma membrane
phospholipase C-activating angiotensin-activated signaling pathway
postsynaptic actin cytoskeleton organization
positive regulation of endocytic recycling
response to hypoxia
vesicle transport along actin filament
positive regulation of cell migration
positive regulation of sodium:proton antiporter activity
tumor necrosis factor-mediated signaling pathway
positive regulation of transcription from RNA polymerase II promoter
negative regulation of substrate adhesion-dependent cell spreading
positive regulation of NIK/NF-kappaB signaling
actin filament organization
platelet activation
platelet formation
platelet morphogenesis
actin filament network formation
platelet aggregation
postsynapse organization
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support