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Invitrogen
IkB zeta Polyclonal Antibody
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Product Details
PA5-104332
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human NFKBIZ(Accession Q9BYH8), corresponding to amino acid residues M280-P330.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total NFKBIZ.
Target Information
I-kappa-B-zeta (also known as MAIL and INAP) is an ankyrin-repeat-containing nuclear protein that is highly homologous to the IkappaB family member Bcl-3. Transcription of IkappaBzeta is upregulated by stimulation with TLR ligands, IL-1 and IL-6 in cultured B-lymphocytes and monocytes/macrophages, but only faintly so in T-lymphocytes, fibroblasts, and endothelial cells. IkappaB-zeta preferentially associates with the NF-kappaB subunit p50 rather than p65 and recombinant IkappaB-zeta proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ30225; FLJ34463; I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta; IkB-zeta; IL-1 inducible nuclear ankyrin-repeat protein; INAP; MAIL; Molecule possessing ankyrin repeats induced by lipopolysaccharide; molecule possessing ankyrin-repeats induced by lipopolysaccharide; NF-kappa-B inhibitor zeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta; OTTHUMP00000214340; unnamed protein product
Gene Aliases: AA408868; I-kappa-B-zeta; IkappaB-zeta; ikappaBzeta; ikB-zeta; IKBZ; INAP; MAIL; NFKBIZ
UniProt ID: (Human) Q9BYH8, (Mouse) Q9EST8
Entrez Gene ID: (Human) 64332, (Mouse) 80859
toll-like receptor signaling pathway
adaptive immune response
lymphocyte activation involved in immune response
plasma cell differentiation
T cell mediated immunity
chronic inflammatory response
chromatin organization
chromatin remodeling
transcription from RNA polymerase II promoter
inflammatory response
response to xenobiotic stimulus
gene expression
regulation of gene expression
immunoglobulin mediated immune response
cytokine-mediated signaling pathway
keratinocyte differentiation
T cell differentiation
positive regulation of defense response
response to lipopolysaccharide
keratinocyte activation
response to cytokine
B cell proliferation
mRNA transcription from RNA polymerase II promoter
skin development
keratinocyte proliferation
T-helper 1 cell differentiation
isotype switching
positive regulation of transcription from RNA polymerase II promoter
spleen development
homeostasis of number of cells within a tissue
positive regulation of inflammatory response
regulation of immune response
defense response to Gram-negative bacterium
T cell receptor signaling pathway
B cell receptor signaling pathway
response to folic acid
establishment of skin barrier
transcription preinitiation complex assembly
cellular response to lipopolysaccharide
cellular response to cytokine stimulus
cellular response to transforming growth factor beta stimulus
T-helper 17 cell differentiation
response to cisplatin
inflammatory response to wounding
execution phase of apoptosis
cellular response to interleukin-17
skin epidermis development
response to Gram-positive bacterium
epithelial cell apoptotic process
B cell receptor apoptotic signaling pathway
positive regulation of T-helper 17 cell differentiation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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