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Invitrogen

Sodium Channel Pan Polyclonal Antibody

View all (17) Sodium Channel Pan antibodies

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Sodium Channel Pan Polyclonal Antibody

Product Details

PA5-104465

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (IHC)

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human SCN1A(Accession P35498), corresponding to amino acid residues F1486-D1536.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2853766

Product Specific Information

Antibody detects endogenous levels of total pan Sodium Channel.

Target Information

Voltage-gated sodium channels (NaV) are essential for the generation of action potentials and for cell excitability. NaV channels are activated in response to depolarization and selectively allow flow of Na+ ions. To date, nine NaV alpha subunits have been cloned and named NaV1.1-NaV1.9. The NaV channels are classified into two groups according to their sensitivity to tetrodotoxin (TTX): TTX-sensitive (NaV1.1, NaV1.2, NaV1.3, NaV1.4, NaV1.6 and NaV1.7) and TTX-resistant (NaV1.5, NaV1.8 and NaV1.9). Mammalian sodium channels are heterotrimers, composed of a central, pore-forming alpha subunit and two auxiliary beta subunits. The expression of the alpha subunit isoform is developmentally regulated and tissue specific. Sodium channels in the adult central nervous system and heart contain beta 1 through beta 4 subunits, whereas sodium channels in adult skeletal muscle have only the beta 1 subunit.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 3-Feb; alternative product; ataxia 3; brain III voltage-gated sodium channel; cardiac tetrodotoxin-insensitive voltage-dependent sodium channel alpha subunit; CTC-264K15.6; H1B; HBSC II; hH1; hH1c; voltage-gated sodium channel; hNa6/Scn8a voltage-gated sodium channel; hNaN; hNE-Na; mH1; Mu-1; Na+ channel; NaCh6; NaN; NaN alpha subunit; Nav1.4; Nav1.5/SCN5A.3; Neuroendocrine sodium channel; Peripheral nerve protein type 4; Peripheral nerve sodium channel 3; Peripheral nerve sodium channel 5; Peripheral sodium channel 1; PN1; PN3; PN4; PN5; RIIA sodium channel protein; SCN10A/PN3; scn5a-JEJ, HH1, hNav1.5, LQT3; SCN8A; Sensory neuron sodium channel; Sensory neuron sodium channel 2; skeletal muscle sodium channel alpha subunit; skeletal muscle voltage-dependent sodium channel type IV alpha subunit; SkM1; sodium channel 25; Sodium channel 6; sodium channel alpha-subunit; Sodium channel protein brain I subunit alpha; Sodium channel protein brain II subunit alpha; Sodium channel protein brain III subunit alpha; Sodium channel protein cardiac muscle subunit alpha; Sodium channel protein skeletal muscle subunit alpha; Sodium channel protein type 1 subunit alpha; Sodium channel protein type 10 subunit alpha; Sodium channel protein type 11 subunit alpha; Sodium channel protein type 2 subunit alpha; Sodium channel protein type 3 subunit alpha; Sodium channel protein type 4 subunit alpha; Sodium channel protein type 5 subunit alpha; Sodium channel protein type 8 subunit alpha; Sodium channel protein type 9 subunit alpha; Sodium channel protein type I subunit alpha; Sodium channel protein type II subunit alpha; Sodium channel protein type III subunit alpha; Sodium channel protein type IV subunit alpha; Sodium channel protein type IX subunit alpha; Sodium channel protein type V subunit alpha; Sodium channel protein type VIII subunit alpha; Sodium channel protein type X subunit alpha; Sodium channel protein type XI subunit alpha; sodium channel protein, brain I alpha subunit; sodium channel protein, brain I subunit alpha; sodium channel protein, brain II subunit alpha; sodium channel protein, brain III subunit alpha; sodium channel protein, brain type 2 alpha subunit; sodium channel type X alpha polypeptide; sodium channel voltage gated type 1 alpha subunit; sodium channel voltage-gated type 11 alpha polypeptide; sodium channel voltage-gated type 4 alpha polypeptide; sodium channel voltage-gated type I alpha polypeptide; sodium channel voltage-gated type II alpha polypeptide; Sodium channel voltage-gated type IV alpha polypeptide; sodium channel voltage-gated type IX alpha; sodium channel voltage-gated type V alpha polypeptide; sodium channel voltage-gated type VIII alpha; sodium channel voltage-gated type VIII alpha polypeptide; sodium channel voltage-gated type X alpha polypeptide; sodium channel voltage-gated type XI alpha polypeptide; sodium channel, voltage gated, type III alpha subunit; sodium channel, voltage gated, type VIII, alpha subunit; sodium channel, voltage-gated, type 1, alpha polypeptide; sodium channel, voltage-gated, type 10, alpha polypeptide; sodium channel, voltage-gated, type 11, alpha polypeptide; sodium channel, voltage-gated, type 2, alpha 1 polypeptide; sodium channel, voltage-gated, type 2, alpha 1 subunit; sodium channel, voltage-gated, type 3, alpha subunit; sodium channel, voltage-gated, type 4, alpha polypeptide; sodium channel, voltage-gated, type 4, alpha subunit; sodium channel, voltage-gated, type 5, alpha subunit; sodium channel, voltage-gated, type 8, alpha polypeptide; sodium channel, voltage-gated, type 8, alpha subunit; sodium channel, voltage-gated, type 9, alpha polypeptide; sodium channel, voltage-gated, type I, alpha polypeptide; sodium channel, voltage-gated, type I, alpha subunit; sodium channel, voltage-gated, type II, alpha 1; sodium channel, voltage-gated, type II, alpha 1 polypeptide; sodium channel, voltage-gated, type II, alpha 2 polypeptide; sodium channel, voltage-gated, type II, alpha polypeptide 1; sodium channel, voltage-gated, type II, alpha subunit; sodium channel, voltage-gated, type III, alpha polypeptide; sodium channel, voltage-gated, type IV, alpha polypeptide; sodium channel, voltage-gated, type IV, alpha subunit; sodium channel, voltage-gated, type IX, alpha polypeptide; sodium channel, voltage-gated, type IX, alpha subunit; sodium channel, voltage-gated, type V, alpha polypeptide; sodium channel, voltage-gated, type V, alpha subunit; sodium channel, voltage-gated, type VIII, alpha polypeptide; sodium channel, voltage-gated, type X, alpha polypeptide; sodium channel, voltage-gated, type X, alpha subunit; sodium channel, voltage-gated, type XI, alpha; sodium channel, voltage-gated, type XI, alpha polypeptide; sodium channel, voltage-gated, type XI, alpha subunit; sodium channel, voltage-gated, type XII, alpha polypeptide; sodium channel, voltage-gated, type11, alpha polypeptide; SP-19; unnamed protein product; voltage gated sodium channel; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated sodium channel Nav1.5c; voltage-gated sodium channel NAV1.9b; voltage-gated sodium channel subtype II; Voltage-gated sodium channel subtype III; Voltage-gated sodium channel subunit alpha Nav1.1; Voltage-gated sodium channel subunit alpha Nav1.2; Voltage-gated sodium channel subunit alpha Nav1.3; Voltage-gated sodium channel subunit alpha Nav1.4; Voltage-gated sodium channel subunit alpha Nav1.5; Voltage-gated sodium channel subunit alpha Nav1.6; Voltage-gated sodium channel subunit alpha Nav1.7; Voltage-gated sodium channel subunit alpha Nav1.8; Voltage-gated sodium channel subunit alpha Nav1.9; voltage-gated sodium channel type II alpha subunit; voltage-gated sodium channel type VIII alpha protein; voltage-gated sodium channel; alpha subunit domain 4, S5-S6

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Gene Aliases: 6430408L10; A230052E19Rik; AI853486; B230332M13; BFIC3; BFIS3; BFIS5; BFNIS; C630029C19Rik; CDCD2; CERIII; CIAT; CMD1E; CMPD2; CMS16; CMYO22A; CMYP22A; DEE11; DEE13; DEE6; DEE62; DEE6A; DEE6B; dmu; DRVT; EA9; EIEE11; EIEE13; EIEE6; EIEE62; ETHA; FEB3; FEB3A; FEB3B; FEPS2; FEPS3; FFEVF4; FHM3; GEFSP2; GEFSP7; Gm1000; HB1; HB2; HBA; HBBD; HBSCI; HBSCII; HH1; HOKPP2; HSAN2D; HSAN7; HYKPP; HYPP; ICCD; IVF; KIAA1356; Kiaa4197; LQT3; MED; mH1; mH2; microI; mKIAA4197; mnd-2; mnd2; MYOCL2; Na(v)1.2; Na(V)1.4; Na(V)1.8; NAC1; NAC1A; NAC2; NAC3; NaCh6; NachII; NaN; NaT; Nav1.1; Nav1.2; Nav1.3; Nav1.4; Nav1.5; Nav1.5c; Nav1.6; Nav1.7; Nav1.8; NAV1.9; Nbna1; NCHVS; NE-NA; NENA; nmf2; nmf335; nmf58; NSS2; nur14; PFHB1; PN1; PN3; PN4; PN5; RII/RIIA; RNSCPIIR; SCAL; SCIII; SCN; SCN1; SCN10A; SCN11A; SCN12A; SCN1A; SCN2A; SCN2A1; SCN2A2; SCN3A; SCN4A; SCN5A; SCN8A; SCN9A; ScpII; seal; SFNP; SkM1; SkM2; SMEI; SNS; SNS-2; SNS2; SSS1; VF1

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UniProt ID: (Human) Q9Y5Y9, (Human) Q9UI33, (Human) P35498, (Human) Q99250, (Human) Q9NY46, (Human) P35499, (Human) Q14524, (Human) Q9UQD0, (Human) Q15858, (Rat) Q62968, (Mouse) Q6QIY3, (Rat) O88457, (Mouse) Q9R053, (Rat) P04774, (Mouse) A2APX8, (Rat) P04775, (Mouse) B1AWN6, (Mouse) A2ASI5, (Rat) P08104, (Mouse) Q9ER60, (Rat) P15390, (Rat) P15389, (Mouse) Q9JJV9, (Mouse) Q9WTU3, (Rat) O88420, (Mouse) Q62205, (Rat) O08562

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Entrez Gene ID: (Human) 6336, (Human) 11280, (Human) 6323, (Human) 6326, (Human) 6328, (Human) 6329, (Human) 6331, (Human) 6334, (Human) 6335, (Rat) 29571, (Mouse) 20264, (Rat) 29701, (Mouse) 24046, (Rat) 81574, (Mouse) 20265, (Rat) 24766, (Mouse) 110876, (Mouse) 20269, (Rat) 497770, (Mouse) 110880, (Rat) 25722, (Rat) 25665, (Mouse) 20271, (Mouse) 20273, (Rat) 29710, (Mouse) 20274, (Rat) 78956

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Function(s)
ion channel activity voltage-gated sodium channel activity cation channel activity sodium channel activity ion channel binding voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential protein binding calmodulin binding fibroblast growth factor binding enzyme binding protein kinase binding protein domain specific binding ankyrin binding ubiquitin protein ligase binding nitric-oxide synthase binding voltage-gated sodium channel activity involved in cardiac muscle cell action potential voltage-gated sodium channel activity involved in AV node cell action potential voltage-gated sodium channel activity involved in bundle of His cell action potential voltage-gated sodium channel activity involved in Purkinje myocyte action potential voltage-gated sodium channel activity involved in SA node cell action potential scaffold protein binding sodium ion binding voltage-gated ion channel activity leucine zipper domain binding nucleotide binding ATP binding voltage-gated ion channel
Process(es)
regulation of heart rate ion transport sodium ion transport sensory perception ion transmembrane transport regulation of ion transmembrane transport sodium ion transmembrane transport odontogenesis of dentin-containing tooth transmembrane transport regulation of cardiac muscle contraction regulation of atrial cardiac muscle cell membrane depolarization cardiac muscle cell action potential involved in contraction membrane depolarization during action potential AV node cell action potential bundle of His cell action potential regulation of presynaptic membrane potential action potential thigmotaxis acute inflammatory response chronic inflammatory response inflammatory response G-protein coupled receptor signaling pathway axonogenesis circadian rhythm chemosensory behavior response to heat response to cold response to xenobiotic stimulus response to toxic substance response to high light intensity response to auditory stimulus transmission of nerve impulse neuronal action potential sensory perception of pain response to prostaglandin E thermosensory behavior regulation of membrane potential mast cell degranulation response to pain behavioral response to pain cell motility detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception establishment of localization in cell reflex micturition skeletal muscle organ development artery development behavioral response to acetic acid induced pain behavioral response to formalin induced pain cellular response to cold calcium ion transmembrane transport response to nitric oxide action potential initiation cAMP/PKA signal transduction sensory perception of itch calcitonin gene-related peptide receptor signaling pathway small intestine smooth muscle contraction adult walking behavior determination of adult lifespan neuronal action potential propagation nerve development neuromuscular process controlling posture nervous system development memory intrinsic apoptotic signaling pathway in response to osmotic stress myelination neuron apoptotic process cellular response to hypoxia muscle contraction regulation of skeletal muscle contraction by action potential cardiac conduction system development cardiac ventricle development brainstem development positive regulation of sodium ion transport response to denervation involved in regulation of muscle adaptation telencephalon development cerebellum development positive regulation of action potential positive regulation of epithelial cell proliferation membrane depolarization cardiac muscle contraction regulation of ventricular cardiac muscle cell membrane repolarization regulation of atrial cardiac muscle cell membrane repolarization regulation of ventricular cardiac muscle cell membrane depolarization cellular response to calcium ion regulation of cardiac muscle cell contraction ventricular cardiac muscle cell action potential membrane depolarization during cardiac muscle cell action potential atrial cardiac muscle cell action potential SA node cell action potential membrane depolarization during AV node cell action potential membrane depolarization during SA node cell action potential membrane depolarization during Purkinje myocyte cell action potential membrane depolarization during bundle of His cell action potential AV node cell to bundle of His cell communication regulation of heart rate by cardiac conduction membrane depolarization during atrial cardiac muscle cell action potential regulation of sodium ion transmembrane transport peripheral nervous system development post-embryonic development action potential propagation cardiac conduction bundle of His cell to Purkinje myocyte communication transport regulation of sensory perception of pain positive regulation of defense response to virus by host response to pyrethroid cellular response to antibiotic response to wounding cation transport potassium ion transport choline transport positive regulation of heart rate response to organic cyclic compound SA node cell to atrial cardiac muscle cell communication muscle organ development sensory perception of sound locomotory behavior adult locomotory behavior neuromuscular process rhythmic excitation
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