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Invitrogen
SCLY Polyclonal Antibody
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FIGURE: 1 / 1
SCLY Antibody (PA5-110344) in WB
Western blot analysis of SCLY in extracts of various cell lines. Samples were incubated with SCLY Polyclonal antibody (Product # PA5-110344) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.
Product Details
PA5-110344
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 284-453 of human SCLY (NP_057594.4).
Conjugate
Form
Liquid
Concentration
3.47 mg/mL
Amount
347 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: FTPLYPMLFG GGQERNFRPG TENTPMIAGL GKAAELVTQN CEAYEAHMRD VRDYLEERLE AEFGQKRIHL NSQFPGTQRL PNTCNFSIRG PRLQGHVVLA QCRVLMASVG AACHSDHGDQ PSPVLLSYGV PFDVARNALR LSVGRSTTRA EVDLVVQDLK QAVAQLEDQA
Target Information
The SCLY gene encodes selenocysteine lyase, an enzyme involved in selenium metabolism, which plays a critical role in the recycling of selenocysteine from selenoproteins. SCLY catalyzes the conversion of selenocysteine into alanine, releasing selenium for reuse in the biosynthesis of new selenoproteins. It is chiefly active in the liver and kidneys, contributing to maintaining selenium homeostasis, which is vital for numerous biological functions due to selenium's role in antioxidant defense and thyroid hormone metabolism. Alterations in SCLY function or expression can affect selenium levels in the body and are associated with disorders related to oxidative stress and metabolic imbalances. Given the importance of selenium in cellular protection and immune function, SCLY is also of interest in studies focusing on dietary supplementation and disease prevention strategies, particularly in conditions like cancer and cardiovascular diseases where oxidative damage is prevalent.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hSCL; mSCL; Selenocysteine lyase; selenocysteine lyase; Selenocysteine reductase; selenocysteine reductase; unnamed protein product
Gene Aliases: 9830169H08; A930015N15Rik; hSCL; SCL; SCLY; Scly1; Scly2
UniProt ID: (Human) Q96I15, (Mouse) Q9JLI6, (Rat) Q68FT9
Entrez Gene ID: (Human) 51540, (Mouse) 50880, (Rat) 363285
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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