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Invitrogen
RAB11A Polyclonal Antibody
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FIGURE: 1 / 4
RAB11A Antibody (PA5-114218) in IHC (P)
Immunohistochemistry of Formalin Fixed Paraffin Embedded Human heart using a RAB11A Polyclonal Antibody (Product # PA5-114218). Observed Staining: Plasma membrane in intercalated disc, cytoplasmic. Primary Antibody Concentration: 1:100. Secondary Antibody: Donkey anti-Rabbit-Cy3 diluted 1:200. Magnification: 20X
Product Details
PA5-114218
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Immunogen sequence: NVEAAFQTIL TEIYRIVSQK QMSDRRENDM SPSNNVVPIH VPPTTENKPK
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: NVEAAFQTIL TEIYRIVSQK QMSDRRENDM SPSNNVVPIH VPPTTENKPK
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 93%
Target Information
Rab11A is a member of the YPT-1 subfamily of Ras-related GTP-binding proteins. Rab11A mRNA has been detected in a variety of tissues including brain, testis, spleen, heart, and gastrointestinal mucosa. In the gastric fundus the Rab11A protein is expressed in parietal cell tubulovesicles membranes. Expression of the Rab11A protein appears to occur in discrete epithelial cell populations where it localizes to apical vesicular populations. Recent studies have shown Rab11A is essential for resecretion of alpha-synuclein out of neuronal cells via endosome recycling and is required for exocytosis of discoidal/fusiform vesicles of bladder umbrella cells. Rab11A is also implicated in biogenesis of Birbeck granules and endosomal activation of the PI3K/AKT signaling pathway via G beta gamma trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GTPase; RAB 11A, member oncogene family; Rab-11; RAB11A; Ras-related protein Rab-11A; unnamed protein product; YL8
Gene Aliases: RAB11; RAB11A; YL8
UniProt ID: (Human) P62491
Entrez Gene ID: (Human) 8766
mitotic cytokinesis
exocytosis
vesicle docking involved in exocytosis
microtubule-based movement
mitotic metaphase plate congression
positive regulation of epithelial cell migration
positive regulation of G2/M transition of mitotic cell cycle
protein transport
vesicle-mediated transport
astral microtubule organization
neuron projection development
melanosome transport
regulation of cytokinesis
protein localization to cell surface
multivesicular body assembly
Golgi to plasma membrane protein transport
positive regulation of cilium assembly
regulation of long-term neuronal synaptic plasticity
plasma membrane to endosome transport
regulation of protein transport
establishment of vesicle localization
regulation of vesicle-mediated transport
early endosome to recycling endosome transport
protein localization to cilium
protein transmembrane transport
establishment of protein localization to organelle
protein localization to plasma membrane
establishment of protein localization to membrane
mitotic spindle assembly
vesicle-mediated transport to the plasma membrane
neurotransmitter receptor transport, endosome to postsynaptic membrane
vesicle-mediated transport in synapse
synaptic vesicle endosomal processing
amyloid-beta clearance by transcytosis
regulation of cilium assembly
regulation of early endosome to recycling endosome transport
positive regulation of protein localization to plasma membrane
positive regulation of mitotic cytokinetic process
regulation of protein localization to centrosome
protein localization to cleavage furrow
exosomal secretion
regulation of endocytic recycling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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