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Invitrogen
MVP Polyclonal Antibody
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FIGURE: 1 / 3
MVP Antibody (PA5-115604) in IHC (P)
Immunohistochemistry analysis of MVP in rat brain tissue. Samples were treated with formaldehyde and treated with citrate buffer for antigen retrieval, blocked, and incubated (1.5 hours at 22°C) with polyclonal antibody (Product # PA5-115604) at a dilution of 1:100. Secondary staining was applied with HRP conjugated goat anti-rabbit.
Product Details
PA5-115604
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MVP(Accession Q14764), corresponding to amino acid residues M1-A46.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MVP.
Target Information
This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences; however, the open reading frames are the same in both transcripts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: lrp; Lung resistance-related protein; Major vault protein; MVP; MVP1; Testicular Secretory Protein Li 30; unnamed protein product; VAULT1; vRNP
Gene Aliases: 2310009M24Rik; LRP; MVP; VAULT1
UniProt ID: (Human) Q14764, (Rat) Q62667, (Mouse) Q9EQK5
Entrez Gene ID: (Human) 9961, (Rat) 64681, (Mouse) 78388
cell proliferation
protein transport
negative regulation of protein autophosphorylation
ERBB signaling pathway
negative regulation of epidermal growth factor receptor signaling pathway
mRNA transport
negative regulation of protein tyrosine kinase activity
protein activation cascade
negative regulation of signaling
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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