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Invitrogen
ARTS Polyclonal Antibody
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FIGURE: 1 / 6
ARTS Antibody (PA5-115882) in ICC/IF
Immunocytochemistry analysis of ARTS in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-115882) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goat anti-mouse IgG (Green) and DAPI (blue) using a dilution of 1:200 (1 hr at 37°C).
Product Details
PA5-115882
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human SEPT4(Accession O43236), corresponding to amino acid residues S86-R136.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total SEPT4.
Target Information
Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-beta signaling pathway. ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-beta and, to a lesser extent, by other apoptotic agents, such as TNF-a and Fas ligand.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 4-Sep; Apoptosis-related protein in the TGF-beta signaling pathway; Arts; Bradeion beta; Brain protein H5; CE5B3 beta; Cell division control-related protein 2; cell division control-related protein 2b; cerebral protein 7; expression gene 3 in rat visual cortex; expression gene 3-1 in rat visual cortex; hCDCREL-2; M-Septin; peanut-like 2; peanut-like 2 homolog; Peanut-like protein 2; PNUTL2; SEPT4 isoform 2; SEPT4_i2; septin H5; Septin-4; septin-M; similar to mouse brain protein h5; uncharacterized protein C17orf47; unnamed protein product
Gene Aliases: ARTS; Bh5; BRADEION; C17orf47; CE5B3; EG3-1RVC; EG3RVC; Gm11492; H5; hCDCREL-2; hucep-7; MART; OTTMUSG00000001265; Pnut12; PNUTL2; SEP4; SEPT4; Septin-4; SEPTIN4; SPGF99
UniProt ID: (Human) O43236, (Mouse) P28661, (Rat) A0A096MJN4
Entrez Gene ID: (Human) 5414, (Mouse) 18952, (Rat) 287606
neuron migration
apoptotic process
spermatogenesis
protein localization
regulation of exocytosis
cell differentiation
sperm motility
positive regulation of protein ubiquitination
regulation of apoptotic process
positive regulation of apoptotic process
spermatid differentiation
cell division
hematopoietic stem cell homeostasis
cytoskeleton-dependent cytokinesis
positive regulation of intrinsic apoptotic signaling pathway
cell cycle
spermatid development
brain development
sperm mitochondrion organization
sperm capacitation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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