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Invitrogen
KMT2E Polyclonal Antibody
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FIGURE: 1 / 4
KMT2E Antibody (PA5-117037) in IHC (P)
Immunohistochemistry analysis of KMT2E in paraffin-embedded rat spleen. Samples were incubated with KMT2E Polyclonal antibody (Product # PA5-117037) using a dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Product Details
PA5-117037
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
0.57 mg/mL
Amount
57 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive Samples: NCI-H460, 293T, Mouse brain
Immunogen sequence: VELYTAFQHT PTSITLTASR VSKVNDKRRK KSGEKEQHIS KCKKAFREGS RKSSRVKGSA PEIDPSSDGS NFGWETKIKA WMDRYEEANN NQYSEGVQRE AQRIALRLGN GNDKKEMNKS DLNTNNLLFK PPVESHIQKN KKILKSAKDL PPDALIIEYR GKFMLREQFE ANGYFFKRPY PFVLFYSKFH GLEMCVDART FGNEARFIRR SCTPNAEVRH EIQDGTIHLY IYSIHSIPKG TEITIAFDFD YGNCKYKVDC ACLKENPECP VLKRSSESME NINSGYETRR KKGKKDKDIS K
Target Information
The mixed lineage leukemia (MLL) gene family comprise a group of Histone H3 lysine 4 (H3K4) methyltransferases within the larger SET1 family. The founding member MLL commonly undergoes translocations in infantile leukemia and displays increased expression in some adult myeloid leukemias. MLL2, also designated ALR, exists within a complex of proteins. MLL2 is important for mouse embryonic development and may be involved in adhesion-related cytoskeletal events affecting cell growth and survival. The MLL2 gene maps to the human locus 19q13.1, which is a frequent target of rearrangement or amplification in solid tumors. MLL3 or its paralogue MLL4 associate with activating signal cointegrator-2 (ASC-2), which regulates ligand-dependent H3K4 trimethylation and expression of LXR-target genes. MLL3 maps to a location on human chromosome 7 that is often deleted in myeloid disorders. MLL3 also exhibits higher expression in peripheral blood, placenta, pancreas, testis, and fetal thymus. MLL5 localizes to the nucleus and forms intranuclear protein complexes, which may regulate chromatin remodeling and cellular growth suppression. The gene encoding human MLL5 lies within chromosome band 7q22.3, a region deleted in cytogenetic aberrations of acute myeloid malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternatively spliced; histone-lysine N-methyltransferase 2E; histone-lysine N-methyltransferase MLL5; Inactive histone-lysine N-methyltransferase 2E; Inactive lysine N-methyltransferase 2E; lysine (K)-specific methyltransferase 2E; lysine N-methyltransferase 2E; MGC70452; MLL5; myeloid/lymphoid or mixed-lineage leukemia 5; myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila); Myeloid/lymphoid or mixed-lineage leukemia protein 5; Myeloid/lymphoid or mixed-lineage leukemia protein 5 homolog; unnamed protein product
Gene Aliases: 1810033J14Rik; 9530077A04Rik; D230038D11Rik; HDCMC04P; KMT2E; MLL5; NKp44L; ODLURO; SETD5B
UniProt ID: (Human) Q8IZD2, (Mouse) Q3UG20
Entrez Gene ID: (Human) 55904, (Mouse) 69188, (Rat) 311968
transcription coactivator activity
protein binding
zinc ion binding
enzyme binding
metal ion binding
histone H3K4me3 reader activity
histone H3 methyltransferase activity
methyltransferase activity
transferase activity
histone-lysine N-methyltransferase activity
histone methyltransferase activity (H3-K4 specific)
molecular_function
neutrophil mediated immunity
chromatin organization
regulation of transcription, DNA-templated
regulation of gene expression
erythrocyte differentiation
regulation of gene expression, epigenetic
neutrophil activation
positive regulation of transcription, DNA-templated
regulation of cell cycle
positive regulation of G1/S transition of mitotic cell cycle
DNA methylation
transcription, DNA-templated
cell cycle
cell cycle arrest
chromatin modification
positive regulation of granulocyte differentiation
methylation
retinoic acid receptor signaling pathway
histone H3-K4 methylation
cellular response to retinoic acid
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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