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Invitrogen

Nodal Polyclonal Antibody

View all (24) Nodal antibodies

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Nodal Polyclonal Antibody

Product Details

PA5-118881

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NODAL(Accession Q96S42), corresponding to amino acid residues L258-V308.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2903381

Product Specific Information

Antibody detects endogenous levels of total NODAL.

Target Information

NODAL is an important TGF-beta family protein in cellular differentiation. While constitutively expressed in many developing tissues, NODAL is problematically associated with the differentiation and development of many cancers. The expression of NODAL is regulated by a Notch signaling pathway, which when disrupted contributes to the aggressive behavior of metastatic cancer cells, particularly in melanoma. The abundance of NODAL expression in melanoma can help determine the stage of cancer and metastatic type/progression when tested in IHC. NODAL interactions with Cripto also predispose toward tumor progression. Overexpression of NODAL is also associated with preeclamptic placenta.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: early embryo mesoderm formation; MGC138230; Nodal; Nodal homolog; transgenic lethal 413.d

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Gene Aliases: HTX5; NODAL; Tg.413d

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UniProt ID: (Human) Q96S42, (Mouse) P43021

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Entrez Gene ID: (Human) 4838, (Rat) 294503, (Mouse) 18119

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Function(s)
cytokine activity protein binding growth factor activity morphogen activity receptor agonist activity type I activin receptor binding transforming growth factor beta receptor binding growth factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development gastrulation with mouth forming second formation of primary germ layer mesoderm formation trophectodermal cell differentiation trophectodermal cellular morphogenesis neural fold formation liver development placenta development embryonic placenta development maternal placenta development vasculature development heart looping inhibition of neuroepithelial cell differentiation determination of left/right asymmetry in lateral mesoderm transmembrane receptor protein serine/threonine kinase signaling pathway transforming growth factor beta receptor signaling pathway germ cell development determination of left/right symmetry gastrulation nervous system development brain development endoderm development heart development female pregnancy cell proliferation positive regulation of cell proliferation embryonic pattern specification anterior/posterior axis specification anterior/posterior pattern specification regulation of signal transduction polarity specification of proximal/distal axis regulation of gastrulation positive regulation of vascular endothelial growth factor production negative regulation of cell development cell migration stem cell population maintenance positive regulation of cell-cell adhesion cell differentiation lung development floor plate morphogenesis somatic stem cell population maintenance embryonic heart tube development endodermal cell differentiation nodal signaling pathway cell migration involved in gastrulation cell fate commitment negative regulation of cell differentiation positive regulation of angiogenesis positive regulation of transcription from RNA polymerase II promoter axial mesodermal cell fate specification mesendoderm development digestive tract morphogenesis anatomical structure formation involved in morphogenesis embryonic cranial skeleton morphogenesis tissue morphogenesis formation of anatomical boundary positive regulation of epithelial cell proliferation digestive system development embryonic process involved in female pregnancy maternal process involved in parturition positive regulation of SMAD protein import into nucleus left lung morphogenesis negative regulation of androgen receptor signaling pathway epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification positive regulation of ERK1 and ERK2 cascade primitive streak formation apoptotic signaling pathway negative regulation of trophoblast cell migration negative regulation of chorionic trophoblast cell proliferation regulation of stem cell population maintenance negative regulation of reproductive process positive regulation of pathway-restricted SMAD protein phosphorylation positive regulation of activin receptor signaling pathway growth regulation of apoptotic process positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of MAPK cascade cell development positive regulation of sequence-specific DNA binding transcription factor activity SMAD protein signal transduction transforming growth factor beta receptor signaling pathway involved in primitive streak formation nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry positive regulation of receptor activity multicellular organism development
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