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Invitrogen

IRAK-M Polyclonal Antibody

View all (28) IRAK-M antibodies

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IRAK-M Polyclonal Antibody

Product Details

PA5-120919

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 367-596 of human IRAK3 (NP_009130.2).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

3.39 mg/mL

Amount

339 µg

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2914491

Product Specific Information

Positive test controls include: THP-1, NCI-H125, Rat liver.

Immunogen sequence: VLTGCRVVLD DPKHIQLRDL LRELMEKRGL DSCLSFLDKK VPPCPRNFSA KLFCLAGRCA ATRAKLRPSM DEVLNTLEST QASLYFAEDP PTSLKSFRCP SPLFLENVPS IPVEDDESQN NNLLPSDEGL RIDRMTQKTP FECSQSEVMF LSLDKKPESK RNEEACNMPS SSCEESWFPK YIVPSQDLRP YKVNIDPSSE APGHSCRSRP VESSCSSKFS WDEYEQYKKE

Target Information

IRAK3 serine/threonine kinase or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which are essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAK3 mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis. Mutations in IRAK3 are associated with a susceptibility to asthma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ13601; IL-1 receptor-associated kinase M; Inactive IL-1 receptor-associated kinase 3; Interleukin-1 receptor-associated kinase 3; IRAK-3; IRAK-M; irak3; unnamed protein product

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Gene Aliases: 4833428C18Rik; AI563835; ASRT5; IRAK-M; IRAK3; IRAKM

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UniProt ID: (Human) Q9Y616, (Mouse) Q8K4B2

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Entrez Gene ID: (Human) 11213, (Mouse) 73914, (Rat) 314870

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Function(s)
nucleotide binding magnesium ion binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding protein kinase binding protein homodimerization activity protein heterodimerization activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups molecular_function
Process(es)
negative regulation of cytokine-mediated signaling pathway toll-like receptor signaling pathway protein phosphorylation apoptotic process signal transduction response to virus positive regulation of macrophage tolerance induction negative regulation of macrophage cytokine production phosphorylation cytokine-mediated signaling pathway negative regulation of NF-kappaB transcription factor activity response to peptidoglycan response to lipopolysaccharide negative regulation of interleukin-12 production negative regulation of interleukin-6 production negative regulation of tumor necrosis factor production negative regulation of toll-like receptor signaling pathway intracellular signal transduction negative regulation of protein catabolic process regulation of apoptotic process negative regulation of protein complex disassembly regulation of protein complex disassembly response to exogenous dsRNA negative regulation of MAP kinase activity negative regulation of innate immune response protein autophosphorylation positive regulation of NF-kappaB transcription factor activity interleukin-1-mediated signaling pathway response to interleukin-1 positive regulation of cytokine production positive regulation of immune system process MyD88-dependent toll-like receptor signaling pathway Toll signaling pathway lipopolysaccharide-mediated signaling pathway positive regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of I-kappaB kinase/NF-kappaB signaling negative regulation of MAPK cascade regulation of innate immune response biological_process
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