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Invitrogen
CYP1A2 Polyclonal Antibody
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Product Details
PA5-142817
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide with sequence C-HSENYKDNGGLIPEEK (aa 289-304).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Additional Information: This antibody is not expected to cross-react to the similar P450 1A1.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:32,000.
Target Information
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aromatic compound inducible; aryl hydrocarbon hydroxylase; Cholesterol 25-hydroxylase; CYP; CYPIA2; Cytochrome P(3)450; Cytochrome P-448; cytochrome P-450 peptide; Cytochrome P-450d; Cytochrome P450 1A2; Cytochrome P450 4; cytochrome P450 family 1 subfamily a polypeptide 1; Cytochrome P450 subfamily I (aromatic compound-inducible) member A2 (Q42 form d); cytochrome P450, 1a2; cytochrome P450, 1a2, aromatic compound inducible; cytochrome P450, family 1, subfamily A, polypeptide 2; cytochrome P450, subfamily I (aromatic compound-inducible), member A2 (Q42, form d); cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 2; Cytochrome P450-D; Cytochrome P450-P2; Cytochrome P450-P3; dioxin-inducible P3-450; flavoprotein-linked monooxygenase; Hydroperoxy icosatetraenoate dehydratase; microsomal monooxygenase; P(3)450; P-448; P450; P450 4; P450 form 4; P450-D; P450-P3; unnamed protein product; xenobiotic monooxygenase
Gene Aliases: CP12; Cyp1a-2; Cyp1a1; CYP1A2; CYPD45; CYPIA2; P-450d; P3-450; P450(PA); P450-3; RATCYPD45
UniProt ID: (Human) P05177, (Mouse) P00186, (Rat) Q64588
Entrez Gene ID: (Human) 1544, (Mouse) 13077, (Rat) 24297
monooxygenase activity
iron ion binding
protein binding
steroid hydroxylase activity
electron carrier activity
oxidoreductase activity
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
lyase activity
enzyme binding
heme binding
demethylase activity
caffeine oxidase activity
metal ion binding
estrogen 16-alpha-hydroxylase activity
estrogen 2-hydroxylase activity
hydroperoxy icosatetraenoate dehydratase activity
aromatase activity
steroid catabolic process
cellular aromatic compound metabolic process
porphyrin-containing compound metabolic process
toxin biosynthetic process
toxin metabolic process
post-embryonic development
alkaloid metabolic process
regulation of gene expression
monoterpenoid metabolic process
drug metabolic process
dibenzo-p-dioxin metabolic process
lung development
monocarboxylic acid metabolic process
drug catabolic process
exogenous drug catabolic process
cellular respiration
heterocycle metabolic process
hydrogen peroxide biosynthetic process
oxidation-reduction process
oxidative demethylation
cellular response to cadmium ion
oxidative deethylation
lipid metabolic process
fatty acid metabolic process
xenobiotic metabolic process
steroid metabolic process
cholesterol metabolic process
estrogen metabolic process
arachidonic acid metabolic process
epoxygenase P450 pathway
methylation
xenobiotic catabolic process
hormone metabolic process
retinol metabolic process
long-chain fatty acid biosynthetic process
aflatoxin metabolic process
omega-hydroxylase P450 pathway
olefinic compound metabolic process
response to organic substance
response to organic cyclic compound
response to estradiol
response to lipopolysaccharide
response to immobilization stress
response to drug
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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