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Invitrogen
NUP98 Polyclonal Antibody
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FIGURE: 1 / 3
NUP98 Antibody (PA5-144272) in ICC/IF
Immunocytochemistry analysis of A549 cells with NUP98 polyclonal antibody (Product # PA5-144272) at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).
Product Details
PA5-144272
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Nuclear pore complex protein Nup98-Nup96 protein (965-1110AA)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% Proclin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alternatively spliced; GLFG-repeat containing nucleoporin; Nuclear pore complex protein Nup98-Nup96; nucleoporin; nucleoporin 96; nucleoporin 98kD; nucleoporin 98kDa; Nup98-Nup96; NUP98/PHF23 fusion 2 protein; OTTHUMP00000013954; unnamed protein product
Gene Aliases: ADAR2; ADIR2; NUP196; NUP96; NUP98; Nup98-96
UniProt ID: (Human) P52948
Entrez Gene ID: (Human) 4928
transcription coactivator activity
RNA binding
mRNA binding
protein binding
nuclear localization sequence binding
peptidase activity
serine-type peptidase activity
hydrolase activity
structural constituent of nuclear pore
peptide binding
molecular condensate scaffold activity
promoter-specific chromatin binding
posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery
RNA export from nucleus
proteolysis
protein import into nucleus
nucleocytoplasmic transport
nuclear pore organization
protein transport
telomere tethering at nuclear periphery
positive regulation of transcription, DNA-templated
positive regulation of mRNA splicing, via spliceosome
mRNA transport
nuclear pore complex assembly
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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