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Invitrogen
PEN2 Polyclonal Antibody
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Product Details
PA5-20302
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 13 amino acid peptide from near the amino terminus of human PEN2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is A-20 cell lysate.
PA5-20302 can be used with blocking peptide PEP-0427.
Target Information
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; Liver regeneration-related protein LRRGT00140; LRRGT00140 mRNA; presenilin enhancer 2 homolog; Presenilin enhancer protein 2; unnamed protein product
Gene Aliases: 1700023M09Rik; ACNINV2; MDS033; MSTP064; PEN-2; PEN2; PSENEN; RGD1312037
UniProt ID: (Human) Q9NZ42, (Mouse) Q9CQR7, (Rat) Q6QI68
Entrez Gene ID: (Human) 55851, (Mouse) 66340, (Rat) 292788
membrane protein ectodomain proteolysis
Notch signaling pathway
Notch receptor processing
protein processing
positive regulation of catalytic activity
positive regulation of endopeptidase activity
membrane protein intracellular domain proteolysis
beta-amyloid formation
amyloid precursor protein metabolic process
amyloid precursor protein catabolic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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