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Invitrogen
FOXN1 Polyclonal Antibody
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FIGURE: 1 / 4
FOXN1 Antibody (PA5-21618) in WB
Western Blot analysis of FOXN1 was performed by separating 50 µg of Various tissue extracts by 7.5% SDS-PAGE. Proteins were transferred to a membrane and probed with a FOXN1 Polyclonal Antibody (Product # PA5-21618) at a dilution of 1:500. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Product Details
PA5-21618
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human FOXN1. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Amount
80 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 10% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: 293T, A431, HeLa, HepG2, A549, H1299, HCT116.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
FOXN1 is a 648 amino acid protein belonging to the winged helix/forkhead family It contains 1 fork-head DNA-binding domain and is a transcriptional regulator involved in development. FOXN1 is involved in directing lineage choices of multi-potential progenitor epithelial cells and controls important regulating genes of lympho-epithelial interactions. It modulates keratinocyte differentiation in hair follicles and nail apparatus and its defects lead to T-cell immunodeficiency congenital alopecia, nail dystrophy, macroscopic nudity and an inborn dysgenesis of the thymus.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Forkhead box protein N1; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH-11; HNF-3/forkhead homolog 11; JTK1; Rowett nude; unnamed protein product; winged-helix nude; Winged-helix transcription factor nude
Gene Aliases: D11Bhm185e; Fkh19; FKHL20; FOXN1; HFH-11; Hfh11; nu; nude; Rnu; RONU; TIDAND; TLIND; WHN
UniProt ID: (Human) O15353, (Mouse) Q61575
Entrez Gene ID: (Human) 8456, (Rat) 287469, (Mouse) 15218
transcription regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
hair follicle development
lymphocyte homeostasis
T cell lineage commitment
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
defense response
epidermis development
organ morphogenesis
regulation of gene expression
hemopoiesis
cell differentiation
keratinocyte differentiation
positive regulation of epithelial cell differentiation
regulation of T cell differentiation in thymus
nail development
T cell homeostasis
positive regulation of transcription from RNA polymerase II promoter
blood vessel morphogenesis
thymus development
positive regulation of hair follicle development
lymphoid lineage cell migration into thymus
thymus epithelium morphogenesis
regulation of positive thymic T cell selection
transcription from RNA polymerase II promoter
cell proliferation
epithelial cell proliferation
transcription, DNA-templated
multicellular organism development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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