Search
Invitrogen
Phospholamban Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 5
Phospholamban Antibody (PA5-26004) in IHC (P)
Immunohistochemistry analysis of Phospholamban in formalin fixed and paraffin embedded mouse heart tissue. Samples were incubated with Phospholamban polyclonal antibody (Product # PA5-26004) followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Product Details
PA5-26004
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 1-30 amino acids of human PLB
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Phospholamban (PLB) is a 52 amino acid phosphoprotein which regulates the calcium pump of cardiac sarcoplasmic reticulum (SR). PLB is an oligomer of five identical subunits each having a cytoplasmic and transmembrane domain. The cytoplasmic domain (residues 1 to 25) contains the phosphorylation sites and is highly basic and readily cleaved by proteases whereas the transmembrane domain (residues 25 to 52) is mostly hydrophobic, protease resistant and stabilizes the pentamer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cardiac CMH18; cardiac phospholamban; Phospholamban; PLB; unnamed protein product
Gene Aliases: CMD1P; CMH18; PLB; Plm; PLN
UniProt ID: (Human) P26678, (Rat) P61016, (Mouse) P61014
Entrez Gene ID: (Human) 5350, (Rat) 64672, (Mouse) 18821
regulation of the force of heart contraction
calcium ion transport
cellular calcium ion homeostasis
regulation of heart contraction
response to zinc ion
negative regulation of heart rate
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
negative regulation of ATPase activity
response to insulin
response to testosterone
negative regulation of heart contraction
cardiac muscle tissue development
protein homooligomerization
regulation of calcium ion transport
negative regulation of calcium ion transport
regulation of ryanodine-sensitive calcium-release channel activity
regulation of cardiac muscle cell contraction
adrenergic receptor signaling pathway involved in heart process
regulation of the force of heart contraction by cardiac conduction
regulation of calcium ion import
negative regulation of calcium ion transmembrane transporter activity
regulation of relaxation of muscle
negative regulation of calcium ion binding
regulation of calcium-transporting ATPase activity
negative regulation of calcium-transporting ATPase activity
Notch signaling pathway
negative regulation of catalytic activity
acrosome assembly
spermatogenesis
blood circulation
visual learning
locomotor rhythm
muscle cell cellular homeostasis
circadian sleep/wake cycle, sleep
regulation of cytosolic calcium ion concentration
relaxation of cardiac muscle
regulation of cardiac muscle cell membrane potential
negative regulation of calcium ion import
regulation of relaxation of cardiac muscle
negative regulation of calcium ion import into sarcoplasmic reticulum
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support