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Invitrogen
ZPK Polyclonal Antibody
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Product Details
PA5-32173
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of mouse DLK/MAP3K12. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.93 mg/mL
Amount
93 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Recommended positive controls: Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, Mouse brain, mouse embryonic stem cell, rat brain.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ZPK is a member of serine/threonine protein kinase family. This kinase contains a leucine-zipper domain, and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DLK; Dual leucine zipper bearing kinase; dual leucine zipper kinase; dual leucine zipper kinase DLK; leucine zipper protein kinase; Leucine-zipper protein kinase; M3KC; MAPK-upstream kinase; Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase); mitogen activated protein kinase kinase kinase 12; Mitogen-activated protein kinase kinase kinase 12; Mixed lineage kinase; MUK; protein kinase MUK; unnamed protein product; Zipper (leucine) protein kinase; ZPK
Gene Aliases: DLK; HP09298; MAP3K12; MEKK12; MUK; PK; ZPK; ZPKP1
UniProt ID: (Human) Q12852, (Rat) Q63796, (Mouse) Q60700
Entrez Gene ID: (Human) 7786, (Rat) 25579, (Mouse) 26404
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase kinase kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
protein homodimerization activity
protein serine/threonine kinase activator activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
protein phosphorylation
JNK cascade
intracellular signal transduction
post-translational protein modification
positive regulation of transcription, DNA-templated
protein autophosphorylation
regulation of macromolecule metabolic process
positive regulation of ERK1 and ERK2 cascade
regulation of primary metabolic process
negative regulation of motor neuron apoptotic process
activation of MAPKK activity
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
phosphorylation
mitophagy in response to mitochondrial depolarization
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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