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Invitrogen

WNT7A Polyclonal Antibody

View all (9) WNT7A antibodies

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Product Details

PA5-34329

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

20 µg/mL
-
Product Specifications

Species Reactivity

Bat, Bovine, Dog, Chicken, Horse, Guinea pig, Hamster, Human, Mouse, Non-human primate, Pig, Rabbit, Rat, Xenopus

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic 12 amino acid peptide from internal region of human WNT7A.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

50 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS

Contains

0.1% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2551681

Target Information

Wnt-7a belongs to the Wnt family of signaling proteins that play a key role in maintaining the integrity of embryonic and adult tissues. It is expressed in placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family, ultimately leading to the disruption of β-catenin degradation. Intracellular accumulation of β-catenin increases translocation of the protein into the nucleus, where it binds to TCF/LEF transcription factors to induce the expression of numerous genes. Increased Wnt/β-catenin signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: postaxial hemimelia; Protein Wnt-7a; proto-oncogene Wnt7a protein; wingless-related MMTV integration site 7A; wingless-type MMTV integration site 7A; wingless-type MMTV integration site family, member 7A; WNT7a

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Gene Aliases: AI849442; px; SANTOS; tw; Wnt-7a; WNT7A

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UniProt ID: (Human) O00755, (Mouse) P24383

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Entrez Gene ID: (Rabbit) 100355697, (Bovine) 533782, (Horse) 100055450, (Dog) 607180, (Chicken) 374168, (Pig) 100153445, (Human) 7476, (Guinea pig) 100719106, (Chinese hamster) 100772978, (Rat) 114850, (Mouse) 22421

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Function(s)
receptor binding frizzled binding cytokine activity protein binding receptor agonist activity intercellular signal molecule
Process(es)
embryonic axis specification cartilage condensation angiogenesis chondrocyte differentiation apoptotic process neurotransmitter secretion axonogenesis synapse assembly sex differentiation positive regulation of cell proliferation tissue development dorsal/ventral pattern formation positive regulation of endothelial cell migration positive regulation of gene expression skeletal muscle satellite cell activation skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration Wnt signaling pathway cerebellar granule cell differentiation cell proliferation in forebrain central nervous system vasculogenesis establishment of cell polarity cell differentiation neuron differentiation embryonic limb morphogenesis regulation of axon diameter response to estradiol somatic stem cell population maintenance embryonic forelimb morphogenesis embryonic hindlimb morphogenesis wound healing, spreading of epidermal cells non-canonical Wnt signaling pathway synaptic vesicle recycling regulation of cell proliferation embryonic digit morphogenesis negative regulation of apoptotic process response to estrogen cell fate commitment asymmetric protein localization involved in cell fate determination positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JNK cascade somatic stem cell division animal organ development system development stem cell development regulation of epithelial cell proliferation negative regulation of neurogenesis regulation of axonogenesis synapse organization cartilage development positive regulation of protein metabolic process positive regulation of synapse assembly positive regulation of epithelial cell proliferation involved in wound healing uterus development oviduct development canonical Wnt signaling pathway Wnt signaling pathway, planar cell polarity pathway limb development establishment of blood-brain barrier dendritic spine morphogenesis uterus morphogenesis secondary palate development lens fiber cell development cellular response to transforming growth factor beta stimulus presynapse assembly postsynapse assembly regulation of postsynapse organization excitatory synapse assembly positive regulation of excitatory synapse assembly positive regulation of protein localization to presynapse regulation of presynapse assembly regulation of synaptic vesicle exocytosis positive regulation of excitatory postsynaptic potential asymmetric protein localization forelimb morphogenesis hindlimb morphogenesis Wnt signaling pathway involved in wound healing, spreading of epidermal cells wound healing skin morphogenesis reproductive structure development skeletal system morphogenesis palate development positive regulation of canonical Wnt signaling pathway signal transduction cell-cell signaling multicellular organism development organ morphogenesis positive regulation of receptor activity
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