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Invitrogen
GFI1B Polyclonal Antibody
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Product Details
PA5-35249
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 302-330 amino acids from the C-terminal region of human GFI1B
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
200 µg
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
GFI1b (zinc finger protein GFI-1b) is an essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. It is also a component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. GFI1b also acts as a transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. It also cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Mutations affecting the gene are associated with Bleeding disorder, platelet-type 17 (BDPLT17).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: GFI1B; growth factor independent 1B (potential regulator of CDKN1A, translocated in CML); growth factor independent 1B transcription repressor; Growth factor independent protein 1B; Potential regulator of CDKN1A translocated in CML; zinc finger protein; Zinc finger protein Gfi-1b
Gene Aliases: BDPLT17; Gfi-1B; GFI1B; ZNF163B
UniProt ID: (Human) Q5VTD9, (Mouse) O70237
Entrez Gene ID: (Human) 8328, (Mouse) 14582
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
zinc ion binding
metal ion binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor binding
nucleic acid binding
C2H2 zinc finger transcription factor
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
regulation of hemopoiesis
negative regulation of G1/S transition of mitotic cell cycle
transcription, DNA-templated
regulation of transcription, DNA-templated
multicellular organism development
hemopoiesis
myeloid cell differentiation
positive regulation of granulocyte differentiation
regulation of erythrocyte differentiation
regulation of neurogenesis
regulation of histone H3-K4 methylation
negative regulation of histone H3-K4 methylation
positive regulation of histone H3-K9 methylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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