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Invitrogen

CaMKII beta/gamma/delta Polyclonal Antibody

View all (4) CaMKII beta/gamma/delta antibodies

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CaMKII beta/gamma/delta Polyclonal Antibody

Product Details

PA5-36562

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 248-299of human CaMKII beta
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2553587

Product Specific Information

This antibody detects endogenous protein at a molecular weight of 50-80 kDa.

Purity is >95% by SDS-PAGE.

Target Information

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be coexpressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: alternatively spliced; Ca++/calmodulin-dependent protein kinase 2 delta subunit; Ca++/calmodulin-dependent protein kinase II beta subunit; Ca++/calmodulin-dependent protein kinase II delta subunit; Ca++/calmodulin-dependent protein kinase II, delta subunit; Ca2+/calmodulin-dependent protein kinase II; Calcium, calmodulin-dependent protein kinase; Calcium, calmodulin-dependent protein kinase II; Calcium, calmodulin-dependent protein kinase, type II; calcium/calmodulin-dependent protein kinase (CaM kinase) II beta; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase type II beta chain; calcium/calmodulin-dependent protein kinase type II delta chain; calcium/calmodulin-dependent protein kinase type II gamma chain; Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase type II subunit delta; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II; CaM kinase II beta subunit; CaM kinase II delta subunit; CaM kinase II subunit beta; CaM kinase II subunit delta; CaM kinase II subunit gamma; CaM-kinase II beta chain; CaM-kinase II delta chain; caM-kinase II gamma chain; CaMK II; CaMK-II delta subunit; caMK-II subunit beta; caMK-II subunit delta; caMK-II subunit gamma; proline rich calmodulin-dependent protein kinase; protein kinase homolog; unnamed protein product

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Gene Aliases: 2810011D23Rik; 8030469K03Rik; [d]-CaMKII; CAM2; CAMK; CaMK II; CAMK-II; CAMK1; CAMK2; CAMK2B; CAMK2D; CAMK2G; CAMKB; CAMKD; CAMKG; Camki; CaMKIIbeta; Ck2b; Kiaa4163; MRD54; MRD59; RATCAMKI

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UniProt ID: (Human) Q13554, (Human) Q13557, (Human) Q13555, (Rat) P08413, (Mouse) P28652, (Rat) P15791, (Mouse) Q6PHZ2, (Mouse) Q923T9, (Rat) P11730

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Entrez Gene ID: (Human) 816, (Human) 817, (Human) 818, (Rat) 24245, (Mouse) 12323, (Rat) 24246, (Mouse) 108058, (Mouse) 12325, (Rat) 171140

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Function(s)
nucleotide binding actin binding protein kinase activity protein serine/threonine kinase activity calmodulin-dependent protein kinase activity protein binding calmodulin binding ATP binding kinase activity transferase activity identical protein binding protein homodimerization activity protein serine kinase activity sodium channel inhibitor activity titin binding ion channel binding calcium-dependent protein serine/threonine phosphatase activity phospholipase binding transferase activity, transferring phosphorus-containing groups nitric-oxide synthase binding non-receptor serine/threonine protein kinase
Process(es)
protein phosphorylation signal transduction nervous system development positive regulation of neuron projection development regulation of skeletal muscle adaptation cell differentiation protein autophosphorylation regulation of neuronal synaptic plasticity regulation of long-term neuronal synaptic plasticity regulation of synapse structural plasticity regulation of calcium ion transport long-term synaptic potentiation regulation of dendritic spine development positive regulation of dendritic spine morphogenesis positive regulation of synapse maturation regulation of protein localization to plasma membrane regulation of neuron migration regulation of cell growth regulation of the force of heart contraction regulation of membrane depolarization regulation of transcription from RNA polymerase II promoter regulation of heart contraction positive regulation of cardiac muscle hypertrophy regulation of cell communication by electrical coupling positive regulation of cardiac muscle cell apoptotic process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion endoplasmic reticulum calcium ion homeostasis relaxation of cardiac muscle regulation of ryanodine-sensitive calcium-release channel activity regulation of cellular localization cellular response to calcium ion cardiac muscle cell contraction regulation of heart rate by cardiac conduction regulation of cardiac muscle cell action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of cell communication by electrical coupling involved in cardiac conduction regulation of relaxation of cardiac muscle negative regulation of sodium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel regulation of neuron projection development insulin secretion G1/S transition of mitotic cell cycle inhibitory G-protein coupled receptor phosphorylation calcium ion transport peptidyl-serine phosphorylation regulation of synaptic transmission, cholinergic positive regulation of phospholipase A2 activity response to cadmium ion cell projection morphogenesis neuromuscular process controlling balance activation of meiosis involved in egg activation positive regulation of apoptotic signaling pathway phosphorylation response to hypoxia regulation of sodium ion transport regulation of G2/M transition of mitotic cell cycle positive regulation of smooth muscle cell migration peptidyl-threonine phosphorylation cellular potassium ion homeostasis positive regulation of Rac protein signal transduction positive regulation of smooth muscle cell proliferation protein oligomerization cardiac muscle contraction cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade negative regulation of sodium ion transmembrane transporter activity response to oxidative stress multicellular organism development
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