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Invitrogen
HOXD10 Polyclonal Antibody
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FIGURE: 1 / 3
HOXD10 Antibody (PA5-67572) in IHC (P)
Immunohistochemical analysis of HOXD10 in paraffin-embedded Human prostate cancer tissue using (left) HOXD10 Polyclonal Antibody (Product # PA5-67572) at a 1:25 dilution and (right) is treated with synthetic peptide. (Original magnification: x200).
Product Details
PA5-67572
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthesized peptide derived from human HOXD10.
Conjugate
Form
Liquid
Concentration
0.7 mg/mL
Amount
70 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 40% glycerol
Contains
0.05% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Predicted to react with Mouse samples.
Target Information
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: d10; homeo box 4D; homeo box D10; Homeobox protein Hox-4.5; Homeobox protein Hox-4D; Homeobox protein Hox-4E; Homeobox protein Hox-5.3; Homeobox protein Hox-D10; Hox-45
Gene Aliases: AI385591; AI874987; Hox-4.4; Hox-4.5; Hox-5.3; HOX4; HOX4D; HOX4E; Hoxd-10; HOXD10
UniProt ID: (Human) P28358, (Mouse) P28359
Entrez Gene ID: (Human) 3236, (Mouse) 15430
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
sequence-specific DNA binding
homeodomain transcription factor
skeletal system development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
single fertilization
skeletal muscle tissue development
adult locomotory behavior
anterior/posterior pattern specification
proximal/distal pattern formation
regulation of gene expression
spinal cord motor neuron cell fate specification
embryonic limb morphogenesis
forelimb morphogenesis
hindlimb morphogenesis
negative regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
embryonic skeletal system morphogenesis
peripheral nervous system neuron development
neuromuscular process
transcription, DNA-templated
multicellular organism development
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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